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Antiplatelet Effect of Clopidogrel Can Be Reduced by Calcium-Channel Blockers

Seo KD, Kim YD, Yoon YW, Kim JY, Lee KY

PURPOSE: Clopidogrel is metabolized by the hepatic cytochrome P450 (CYP) system into its active thiol metabolite. CYP3A4 is involved in the metabolism of both clopidogrel and dihydropyridine calcium channel blockers...
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