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Cytotoxicity of Diamide and the Protective Effect of Thioredoxin on Diamide-Induced Vasculotoxicity in Vascular Endothelial Cells

Ra EY, Seok JE, Lee EH, Lee CW, Yoon HS, Park ST

BACKGROUND AND OBJECTIVES: This study was designed to examine the effects of diamide and thioredoxin (TRX) on vascular endothelial cells in order to clarify the mechanism by which vascular damage...
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Effects of Thioredoxin on Oxidative Neuronal Cell Injury

Kim H, Kim GH, Lee YS

  • KMID: 2335405
  • J Korean Pediatr Soc.
  • 1999 May;42(5):686-696.
PURPOSE: Thioredoxin is an endogenous antioxidant which directly scavenges reactive oxygen species(ROS) and regenerates oxidatively damaged protein by reducing potential at the redox active disulfide(-Cys-Gly-Pro-Cys-) site. Under oxidative stress, thiredoxin...
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Dual effect of oxidative stress on NF-kappaB activation in HeLa cells

Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM

  • KMID: 755204
  • Exp Mol Med.
  • 2002 Nov;34(5):332-339.
Reactive oxygen species (ROS) has been implicated as an inducer of NF-kappaB activity in numbers of cell types where exposure of cells to ROS such as H2O2 leads to NF-kappaB...
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A Nudix Hydrolase Protein, Ysa1, Regulates Oxidative Stress Response and Antifungal Drug Susceptibility in Cryptococcus neoformans

Lee KT, Kwon H, Lee D, Bahn YS

  • KMID: 2312723
  • Mycobiology.
  • 2014 Mar;42(1):52-58.
A nucleoside diphosphate-linked moiety X (Nudix) hydrolase-like gene, YSA1, has been identified as one of the gromwell plant extract-responsive genes in Cryptococcus neoformans. Ysa1 is known to control intracellular concentrations...
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Effects of Thioredoxin on Apoptosis-Inducing Neuronal Cell Injury

Kim H, Kim GH, Lee YS

  • KMID: 2041987
  • J Korean Pediatr Soc.
  • 1999 Jun;42(6):825-832.
PURPOSE: Thioredoxin is an endogenous antioxidant. It regulates the activities of transcriptional factors such as NF-kB(nuclear factor kappa B)and AP-1(activator protein-1) and it increases the synthesis of cytokines, preventing cellular...
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