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A Correlation between Serum Level of Alkaline Phosphatase and Acne Severity in Children and Adolescents: A Retrospective Cross-Sectional Study

Jue MS, Park E, Kang HS, Kim JS

Background: Acne is a chronic inflammatory disease of the pilosebaceous unit and usually affects adolescents when the peak concentrations of growth hormone, insulin-like growth factor 1, and androgen are demonstrated....
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Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?

Walther A, Seuffert J

Although demographic statistics show that populations around the world are rapidly ageing, this rising life expectancy is accompanied by an increase in the number of people living with age-related chronic...
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Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain

Choi SR, Beitz AJ, Lee JH

We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory...
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Live birth outcomes of vitrified embryos generated under growth hormone stimulation are improved for women categorized as poor-prognosis

Keane KN, Ye Y, Hinchliffe PM, Regan SL, Dhaliwal S, Yovich JL

OBJECTIVE: To determine the clinical pregnancy (CP) and live birth (LB) rates arising from frozen embryo transfers (FETs) that had been generated under the influence of in vitro fertilization (IVF)...
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The association between serum dehydroepiandrosterone sulfate (DHEAS) levels and job-related stress among female nurses

Cho S, Park WJ, Kang W, Lim HM, Ahn JS, Lim DY, Moon JD

BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is an endogenous steroid hormone produced by the adrenal gland. DHEAS has been suggested to play a protective role against psychosocial stress. The aim of this...
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Dehydroepiandrosterone and Erectile Function: A Review

El-Sakka A

To review the contemporary knowledge regarding the dehydroepiandrosterone and erectile function. Medline was reviewed for English-language journal articles spanning the time between January 1990 and December 2017, using the terms...
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Association between Body Mass Index and Serum Dehydroepiandrosterone Sulfate Level in 8-Year-Old Girls

Na JH, Kim YH, Hong SJ, Kim JK

BACKGROUND: Adiposity may play a role as a potential trigger for adrenarche. The purpose of this study was to evaluate the association between body mass index (BMI) and serum dehydroepiandrosterone...
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The association between skeletal maturation and adrenal androgen levels in obese children and adolescents

Kim SE, Jang JW, Ahn MB, Kim SH, Cho WK, Cho KS, Park SH, Jung MH, Suh BK

PURPOSE: This study aimed to investigate the association between skeletal maturation and adrenal androgen levels in obese children and adolescents. METHODS: Fifty-three children and adolescents (aged 7–15 years) diagnosed as obese...
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Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells

Ye DJ, Kwon YJ, Shin S, Baek HS, Shin DW, Chun YJ

Steroid sulfatase (STS) is an enzyme responsible for the hydrolysis of aryl and alkyl sulfates. STS plays a pivotal role in the regulation of estrogens and androgens that promote the...
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Dehydroepiandrosterone Sulfate Level Varies Nonlinearly with Symptom Severity in Major Depressive Disorder

Uh D, Jeong HG, Choi KY, Oh SY, Lee S, Kim SH, Joe SH

OBJECTIVE: The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate biomarkers in MDD have been reported, which might be a consequence of the...
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Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs

Mongillo P, Bernardini M, Prana E, Balducci F, Gabai G, Marinelli

Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid...
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The Association between Dehydroepiandrosterone Sulfate (DHEA-S) and Bone Mineral Density in Korean Men and Women

Park SG, Hwang S, Kim JS, Park KC, Kwon Y, Kim KC

BACKGROUND: The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial. And findings of most studies that have investigated this relationship are restricted to postmenopausal women. In...
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Limited Diagnostic Utility of Plasma Adrenocorticotropic Hormone for Differentiation between Adrenal Cushing Syndrome and Cushing Disease

Hong AR, Kim JH, Hong ES, Kim IK, Park KS, Ahn CH, Kim SW, Shin CS, Kim SY

BACKGROUND: Measurement of the plasma adrenocorticotropic hormone (ACTH) level has been recommended as the first diagnostic test for differentiating between ACTH-independent Cushing syndrome (CS) and ACTH-dependent CS. When plasma ACTH...
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The Relationship between Opioids Use, Cortisol and DHEAS

Jung JH, Choi YS, Kim SM, Lee JY, Kim EH, Kim JE, Kim EY, Park HJ, Yoon DJ

PURPOSE: Fatigue, energy loss, feeling of helplessness, poor appetite, pain besides general weakness are major symptoms presented to terminally ill cancer patients. These symptoms are similar to those that appeared...
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Dehydroepiandrosterone Sulfate as a Risk Factor for Premature Myocardial Infarction: A Comparative Study

Shojaie M, Rajpout MY, Abtahian A, Pour AE, Ghobadifar MA, Akbarzadeh A

BACKGROUND: This study aimed to evaluate some of the major risk factors of myocardial infarction including dehydroepiandrosterone sulfate in patients with premature myocardial infarction (age or =50 years). METHODS: This...
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Opioids Use and Adrenal Insufficiency

Jung JH, Choi YS, Kim JE, Kim EY

The major symptoms of terminally ill cancer patients are fatigue, loss of energy, feeling of helplessness, poor appetite and pain as well as general weakness, which are very similar to...
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Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs

Sah C, Aridogan I, Izol V, Erdogan S, Doran S

  • KMID: 2430623
  • Korean J Urol.
  • 2013 Mar;54(3):199-203.
PURPOSE: This study aimed to determine the effects of the long-term use of dehydroepiandrosterone sulfate (DHEAS) on rat prostates and testes as well as on serum testosterone and DHEAS levels. MATERIALS...
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Gender-Specific Asthma Treatment

Choi IS

Because genetic characteristics vary among subjects, the therapeutic effects of a certain drug differ among patients with the same disease. For this reason, special interest has focused on tailored treatments....
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Adrenal exhaustion and fatigue due to chronic stress

Ahn YW

  • KMID: 2341693
  • J Korean Med Assoc.
  • 2011 Jan;54(1):81-87.
Adrenal fatigue is a symptom complex occurring when chronic stress overwhelms one's own adaptation reserve. Morning fatigue, decreased performance, irritability, depressed mood, poor concentration, general myalgia, insomnia, cravings for stimulants,...
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The Effects of Galantamine Hydrobromide Treatment on Dehydroepiandrosterone Sulfate and Cortisol Levels in Patients with Chronic Fatigue Syndrome

Turan T, Izgi HB, Ozsoy S, Tanriverdi F, Basturk M, Asdemir A, Besirli A, Esel E, Sofuoglu S

  • KMID: 2315838
  • Psychiatry Investig.
  • 2009 Sep;6(3):204-210.
OBJECTIVE: Mental fatigue, cognitive disorders, and sleep disturbances seen in chronic fatigue syndrome (CFS) may be attributed to cholinergic deficit. A functional deficiency of cholinergic neurotransmission may cause the hypothalamic-pituitary-adrenal...
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