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HPLC-UV method for the simultaneous determinations of ascorbic acid and dehydroascorbic acid in human plasma

Kim Y, Kim MG

A high performance liquid chromatography (HPLC) paired with UV-vis detection method to determine ascorbic acid and its oxidation product, dehydroascorbic acid, in human plasma was developed. Ascorbic acid in human...
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Effects of Ascorbic and Dehydroascorbic Acids on Apoptotic Cell Death in Hippocampal Slice Culture

Kim EJ, Won R, Lee KH, Kim UJ, Shim I, Lee HJ, Lee BH

Ascorbic acid (AA) and dehydroascorbic acid (DHA) are known to have protective effects in experimental central nerve system disorder models such as stroke, ischemia, and epileptic seizures. The present study...
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Dehydroascorbic Acid Attenuates Ischemic Brain Edema and Neurotoxicity in Cerebral Ischemia: An in vivo Study

Song J, Park J, Kim JH, Choi JY, Kim JY, Lee KM, Lee JE

Ischemic stroke results in the diverse phathophysiologies including blood brain barrier (BBB) disruption, brain edema, neuronal cell death, and synaptic loss in brain. Vitamin C has known as the potent...
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Effects of glutamate on dehydroascorbate uptake and Its enhanced vulnerability to the peroxidation in cerebral cortical slices

Song JH, Shin SH, Chung IM

  • KMID: 1121095
  • Exp Mol Med.
  • 2002 Dec;34(6):419-425.
Pro-oxidant properties of ascorbate have been studied with uses of brain tissues and neuronal cells. Here we address potential mechanism of ascorbate coupling with glutamate to generate oxidative stress,...
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