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Cutaneous Adverse Events of Anti-Programmed Cell Death Receptor-1 Antibody: Two Case Reports and a Literature Review

Lim JS, Kim HH, Kwon ES, Myung KB, Cheong SH

  • KMID: 2520804
  • Korean J Dermatol.
  • 2021 Sep;59(8):644-648.
The introduction of immune checkpoint inhibitors, including anti-programmed cell death receptor-1 antibodies (anti-PD-1 Ab), such as nivolumab and pembrolizumab, represents a major breakthrough in cancer therapy. The PD-1 pathway inhibits...
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End-of-Life Assessments and Communication for Dying Patients and Their Families

Lee EK, Jeong HY, Kim KW

End-of-life assessments aim to help dying patients and their families plan clinical interventions in advance and prepare them for a peaceful end of life, in which the patient accepts life...
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The Effects of a Death Preparation Education Program on Death Anxiety, Death Attitudes, and Attitudes toward End-of-Life Care among Nurses in Convalescent Hospitals

Chu Ey, Jang Sh

Purpose: The purpose of this study was to examine the effects of a death preparation education program for nurses working in convalescent hospitals on death anxiety, death attitudes, and attitudes...
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Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy

Bae Y, Lee J, Kho C, Choi JS, Han J

In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering...
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Evaluation of circulating PD-1 and PD-L1 as diagnostic biomarkers in dogs with tumors

Song DW, Ro WB, Park HM

Background Programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) have important roles in tumor evasion of the immune system. Objectives This study aimed to assess the diagnostic utility of circulating...
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CT and MR Imaging Findings of Structural Heart Diseases Associated with Sudden Cardiac Death

Lee JS, Ko SM, Moon HJ, Ahn JH, Kim HJ, Cha SW

Sudden cardiac death is an unexpected death originating from the heart that occurs within an hour of the onset of symptoms. The main cause of sudden cardiac death is arrhythmia;...
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Trends and Characteristics of Mortality Associated with Congenital Anomalies in Korean Children under 5 Years of Age

Kim SB, Jang MJ, Song YH, Jung SY, Oh JS, Lim JW

Purpose: Studies have been conducted on the prevalence and infant mortality rate of congenital anomalies; however, studies on child mortality are rare. Therefore, we evaluated the characteristics of deaths associated...
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Vanillin oxime inhibits lung cancer cell proliferation and activates apoptosis through JNK/ERK-CHOP pathway

Shen J, Su Z

Lung cancer despite advancement in the medical field continues to be a major threat to human lives and accounts for a high proportion of fatalities caused by cancers globally. The...
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Mortality Rates during Hospitalization and Affecting Factors in Geriatric Delirium Patients: a Retrospective Cohort Study

Özdin S, Bolat R

Background and Purpose: The purpose of this study was to investigate the prevalence of mortality during hospitalization among patients diagnosed with delirium at geriatric consultations requested in the previous one...
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Risk of Death in Colorectal Cancer Patients with Multi-morbidities of Metabolic Syndrome: A Retrospective Multicohort Analysis

Feng Q, Xu L, Li L, Qiu J, Huang Z, Jiang Y, Wen T, Lu S, Meng F, Shu X

Purpose The prevalence of multi-morbidities with colorectal cancer (CRC) is known to be increasing. Particularly prognosis of CRC patients co-diagnosed with metabolic syndrome (MetSyn) was largely unknown. We aimed to...
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Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus

Jeon JY, Ha KH, Kim DJ

Background: Using real-world data, cardiovascular safety was investigated in metformin users newly starting sodium glucose cotransporter 2 (SGLT2) inhibitors compared with other glucose-lowering drugs in Korea. Methods: This was a retrospective...
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Demographic Characteristics of Body Donation Program Database at Jeju National University Medical School

Kang WS, Kim J, Yoon SP

Dissections for medical education have been performed with one donated and died unclaimed. Recently, ‘The Revised Act of Corpse Dissection and Preservation’ prohibited the use of the unclaimed dead bodies...
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Diabesity Associates with Poor COVID-19 Outcomes among Hospitalized Patients

Nikniaz Z, Somi MH, Dinevari MF, Taghizadieh A, Mokhtari L

Background: Although numerous studies have investigated obesity’s negative effect on coronavirus disease 2019 (COVID-19) outcomes, only a limited number focused on this association in diabetic patients. In this study, we...
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Organ donation after controlled circulatory death (Maastricht classification III) following the withdrawal of life-sustaining treatment in Korea: a suggested guideline

Park H, Jung ES, Oh JS, Lee YM, Lee JM

The “Act on hospice and palliative care and decisions on life-sustaining treatment for patients at the end of life” was enacted in February 2018 in Korea. Therefore, we suggest a...
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The Effect of Hospice Patients' Pain, Anxiety, Depression, Perception of Dignity, and Spiritual Well-Being on their Attitudes toward Dignified Death

Ahn YS, Oh PJ

Purpose: This study aimed to examine the effect of pain, anxiety, depression, perception dignity, and spiritual well-being on hospice patients’ attitudes toward dignified death. Methods: A total of 130 terminal...
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First Organ Donation after Circulatory Death Following Withdrawal of Life-sustaining Treatment in Korea: a Case Report

Jeong E, Baik S, Park H, Oh J, Lee Y, Lee Jm

In February 2018, the Withdrawal of the Life-sustaining Treatment (WLST) Decision Act was legalized in Korea. Donation after circulatory death (DCD) after WLST was classified as DCD category III. We...
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Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves’ Disease and Hashimoto’s Thyroiditis in Korean Patients

Yoon JH, Shin Mh, Kim HN, Choi W, Park JY, Hong AR, Kim HK, Kang HC

Background: Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programmed death 1 (PD-1) on immune cells, which could prevent the exacerbation of...
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Practical Considerations in Providing End-of-Life Care for Dying Patients and Their Family in the Era of COVID-19

Kim Y, Yoo SH, Shin JM, Han HS, Hong J, Kim HJ, Choi W, Kim MS, Park HY, Keam B

In the era of coronavirus disease 2019 (COVID-19), social distancing and strict visitation policies at hospitals have made it difficult for medical staff to provide high-quality endof-life (EOL) care to...
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Novel Methods of Necroptosis Inhibition for Spinal Cord Injury Using Translational Research to Limit Secondary Injury and Enhance Endogenous Repair and Regeneration

Fiani B, Kondilis A, Soula M, Tao A, Alvi MA

Spinal cord injuries (SCIs) pose an immense challenge from a clinical perspective as current treatments and interventions have been found to provide marginal improvements in clinical outcome (with varying degrees...
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Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS

Leem YH, Park JS, Park JE, Kim DY, Kim HS

Microglial priming is the process of microglial proliferation and activation in response to neurodegeneration and abnormal protein accumulation. Priming makes microglia susceptible to secondary inflammatory stimuli and causes exaggerated inflammatory...
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