- PIK3CA H1047R Mutation Associated with a Lower Pathological Complete Response Rate in Triple-Negative Breast Cancer Patients Treated with Anthracycline-Taxane–Based Neoadjuvant Chemotherapy
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Guo S, Loibl S, von Minckwitz G, Darb-Esfahani S, Lederer B, Denkert C
- KMID: 2504451
- Cancer Res Treat.
- 2020 Jul;52(3):689-696.
- doi: 10.4143/crt.2019.497
Purpose PIK3CA, encoding for subunit p110a of phosphatidylinositol 3 kinase, is frequently mutated in breast cancer. PIK3CAmutation was predictive for pathological complete response (pCR) in human epidermal growth factor 2 positive... -
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- Checkpoint-inhibition in ovarian cancer: rising star or just a dream?
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Pietzner K, Nasser S, Alavi S, Darb-Esfahani S, Passler M, Muallem MZ, Sehouli J
- KMID: 2431238
- J Gynecol Oncol.
- 2018 Nov;29(6):e93.
- doi: 10.3802/jgo.2018.29.e93
The introduction of checkpoint inhibitors revolutionized immuno-oncology. The efficacy of traditional immunotherapeutics, like vaccines and immunostimulants was very limited due to persistent immune-escape strategies of cancer cells. Checkpoint inhibitors target... -
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- Overexpression of the epithelial cell adhesion molecule is associated with a more favorable prognosis and response to platinum-based chemotherapy in ovarian cancer
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Woopen H, Pietzner K, Richter R, Fotopoulou C, Joens T, Braicu EI, Mellstedt , Mahner S, Lindhofer , Darb-Esfahani S, Denkert C, Sehouli J
- KMID: 2130103
- J Gynecol Oncol.
- 2014 Jul;25(3):221-228.
- doi: 10.3802/jgo.2014.25.3.221
OBJECTIVE: Epithelial cell adhesion molecule (EpCAM) has experienced a renaissance lately as a binding site for targeted therapy as well as a prognostic marker in epithelial malignancies. Aim of this... -
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