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Lithium and Valproate in Bipolar Disorder: From International Evidence-based Guidelines to Clinical Predictors

Crapanzano C, Casolaro I, Amendola C, Damiani S

Since decades, lithium and valproate remain the pharmacological cornerstone to treat bipolar disorder. Different response patterns occur according to the phases of illness. At same time, individual pretreatment variables may...
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Efficacy of Olanzapine in Anxiety Dimension of Schizophrenia: A Systematic Review of Randomized Controlled Trials

Crapanzano C, Casolaro I, Damiani S, Amendola C

Anxiety symptoms and anxiety disorders are frequent in patients with schizophrenia and are associated with greater severity of both positive and negative symptoms, cognitive impairment, poorer functioning and quality of...
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Quetiapine Treatment for Post-traumatic Stress Disorder: A Systematic Review of the Literature

Crapanzano C, Damiani S, Casolaro I, Amendola C

Paroxetine and Sertraline are the only medications approved in posttraumatic stress disorder (PTSD). However, about 60% of traumatized patients fail to show an adequate clinical response. Second generation antipsychotics are...
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The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials

De Cagna F, Fusar-Poli L, Damiani S, Rocchetti , Giovanna G, Mori A, Politi P, Brondino N

Several studies have demonstrated the neuromodulating function of oxytocin (OT) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression. Consequently, intranasal OT (IN-OT)...
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