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The Expression of DNA Dependent Protein Kinase Protein in Malignant Lymphoma

Noh TW, Cho NH, Yang WI

  • KMID: 2275587
  • Korean J Pathol.
  • 2001 Dec;35(6):477-485.
BACKGROUND: DNA dependent protein kinase (DNA-PK) composed of Ku70, Ku80 and DNA-PK catalytic subunit (DNA-PKcs), plays an important role in the primary repair of break points of damaged DNA and...
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Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase

Kim CH, Cuong DV, Kim JS, Kim N, Kim E, Han J

  • KMID: 1607348
  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):9-14.
Recent studies indicated that cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs by enhanced DNA repair of the lesions. Therefore, it is expected to increase the killing...
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p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest

Chae HD, Kim SY, Park SE, Kim J, Shin DY

We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin...
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Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA- PKcs) Expression in Gastric Cancers

Lee HS, Yang HK, Kim WH, Choe G

  • KMID: 1571464
  • Cancer Res Treat.
  • 2005 Apr;37(2):98-102.
PURPOSE: DNA-PKcs is one of the DNA repair genes. It was recently found that hyperplasia and dysplasia of the intestinal mucosa and the production of aberrant crypt foci were developed...
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Expression of Ku Correlates with Radiation Sensitivities in the Head and Neck Cancer Cell Lines

Lee SW, Yu E, Yi SL, Son SH, Kim JH, Ahn SD, Shin SS, Choi EK

  • KMID: 1516697
  • J Korean Soc Ther Radiol Oncol.
  • 2004 Sep;22(3):208-216.
PURPOSE: DNA-dependent protein kinase (DNA-PK) is a serine/threonine kinase consisting of a 470 kDa catalytic subunit (DNA-PKcs) and a heterodimeric regulatory complex, called Ku, which is composed of 70 kDa...
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The Significance of Ku70 Expression in Patients with Nasopharyngeal Carcinoma

Song SY, Lee SW, Yu E, Cho KJ, Park JH, Kim SY, Nam SY, Lee BJ, Kim SB, Choi SH, Ahn SD, Shin SS, Choi EK, Kim JH

  • KMID: 2323835
  • J Korean Soc Ther Radiol Oncol.
  • 2005 Mar;23(1):1-8.
PURPOSE: The objective of this study was to determine whether the expressions of the two components of DNA-dependent protein kinase, Ku70 and DNA-PKcs, influence the response to radiotherapy (RT) and...
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Association between Exudative Age-related Macular Degeneration and the G6721T Polymorphism of XRCC7 in Outdoor Subjects

Saadat I, Vakili-Ghartavol R, Farvardin-Jahromi M, Saadat M

PURPOSE: To investigate whether the G6721T polymorphism (rs.7003908) of the non-homologous end-joining DNA repair XRCC7 gene contributes to the development of exudative age-related macular degeneration (ARMD). METHODS: The present case-control study...
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