- Effects of hOGG1 Associated with the Aging Process on the Development of Benign Prostatic Hyperplasia
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Eom MS, Kim YT, Kim WJ
- KMID: 2292470
- Korean J Urol.
- 2002 Jun;43(6):502-507.
PURPOSE: 8-oxoguanine DNA glycosylase (OGG) repairs DNA by removing 8-oxoguanine (oh8Gua), a highly mutagenic oxidative DNA adduct. Recently, the human gene for OGG (hOGG1) was cloned and several genotypes have... -
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- Base excision repair synthesis of DNA containing 8-oxoguanine in Escherichia coli
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Lee YS, Chung MH
- KMID: 1097258
- Exp Mol Med.
- 2003 Apr;35(2):106-112.
8-oxo-7,8-dihydroguanine (8-oxo-G) in DNA is a mutagenic adduct formed by reactive oxygen species. In Escherichia coli, 2,6-dihydroxy-5N-formamidopyrimidine (Fapy)-DNA glycosylase (Fpg) removes this mutagenic adduct from DNA. In this report, we... -
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- Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells
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Wan J, Bae MA, Song BJ
- KMID: 755668
- Exp Mol Med.
- 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify... -
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- Expression of hOGG1 protein during differentiation of HL-60 cells
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Lee YS, Lee KH, Chung MH
- KMID: 1097257
- Exp Mol Med.
- 2003 Apr;35(2):98-105.
Human 8-oxo-G-DNA glycosylase 1 (hOGG1) is a DNA glycosylase to cleave 8-oxo-7,8-dihydroguanine (8-oxo-G), a mutagenic DNA adduct formed by oxidant stresses. Here, we examined hOGG1 protein expression and repair activity... -
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- Effects of Oxidative DNA Damage and Genetic Polymorphism of the Glutathion Peroxidase 1 (GPX1) and 8-Oxoguanine Glycosylase 1 (hOGG1) on Lung Cancer
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Lee CH, Lee KY, Choe KH, Hong YC, Noh SI, Eom SY, Ko YJ, Zhang YW, Yim DH, Kang JW, Kim H, Kim YD
- KMID: 792399
- J Prev Med Public Health.
- 2006 Mar;39(2):130-134.
OBJECTIVES: Oxidative DNA damage is a known risk factor of lung cancer. The glutathione peroxidase (GPX) antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides plays a significant role... -
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