- DNA damage to human genetic disorders with neurodevelopmental defects
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Lee Y, Choi I, Kim J, Kim K
- KMID: 2327696
- J Genet Med.
- 2016 Jun;13(1):1-13.
- doi: 10.5734/JGM.2016.13.1.1
Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich... -
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- DNA Double Strand Breaks in Gastric Epithelium with Helicobacter pylori Infection
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Chang YJ, Byun SW, Kim HK, Cho YS, Kim SS, Kim JI, Kim JK, Jung ES
- KMID: 1387335
- Korean J Gastroenterol.
- 2012 Aug;60(2):79-85.
- doi: 10.4166/kjg.2012.60.2.79
BACKGROUND/AIMS: DNA double strand breaks (DSB) is one of the critical types of DNA damage. If unrepaired, DSB is accumulated in the nucleus of cells, the cells become apoptotic or... -
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- The Expressions of p53, gamma-H(2)AX and Ku70/Ku80 That was Caused by Hydronephrosis in the Kidney of Rats
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Moon C, Moon HY, Kim CS
- KMID: 2061301
- Korean J Urol.
- 2007 Sep;48(9):976-983.
- doi: 10.4111/kju.2007.48.9.976
PURPOSE: There are little research about the factors of DNA damage and repair that might cause renal parenchymal damage under the condition of hydronephrosis. In this study, we studied the... -
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- PREFACE: How Dangerous Are X-ray Studies That We Undertake Every Day?
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Kim DI
- KMID: 2363373
- J Korean Med Sci.
- 2016 Feb;31(Suppl 1):S2-S3.
- doi: 10.3346/jkms.2016.31.S1.S2
No abstract available. -
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- Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines
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Avila-Arroyo S, Nunez GS, Garcia-Fernandez LF, Galmarini
- KMID: 2176281
- J Breast Cancer.
- 2015 Dec;18(4):329-338.
- doi: 10.4048/jbc.2015.18.4.329
PURPOSE: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP)... -
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- Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase
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Kim CH, Cuong DV, Kim JS, Kim N, Kim E, Han J
- KMID: 1607348
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):9-14.
Recent studies indicated that cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs by enhanced DNA repair of the lesions. Therefore, it is expected to increase the killing... -
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- Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma
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Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES
- KMID: 1775922
- Korean J Gastroenterol.
- 2010 Jan;55(1):19-25.
- doi: 10.4166/kjg.2010.55.1.19
BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such... -
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- Clinicopathological values of NBS1 and DNA damage response genes in epithelial ovarian cancers
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Lee YK, Park NH, Lee H
- KMID: 2359882
- Exp Mol Med.
- 2015 Nov;47(11):e195.
- doi: 10.1038/emm.2015.85
Epithelial ovarian cancers (EOCs) are highly lethal gynecological malignancies with a high recurrence rate. Therefore, developing prognostic markers for recurrence after chemotherapy is crucial for the treatment of ovarian cancers.... -
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- Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology
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Kang JT, Kwon DK, Park AR, Lee EJ, Yun YJ, Ji DY, Lee K, Park KW
- KMID: 2363339
- J Vet Sci.
- 2016 Mar;17(1):89-96.
- doi: 10.4142/jvs.2016.17.1.89
Recent developments in genome editing technology using meganucleases demonstrate an efficient method of producing gene edited pigs. In this study, we examined the effectiveness of the transcription activator-like effector nuclease... -
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