- The effects of chromium exposure on sister chromatid exchange and concentration of 8-hydroxydeoxyguanosine
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Han SH, Cho SH, Kim H, Park SM, Ha M, Joo YS, Kwon HJ, Kwon YD, Kwon MH
- KMID: 2282757
- Korean J Prev Med.
- 1995 Jun;28(2):511-525.
To elucidate some DNA adducts as a biological marker for workers of chromate pigment, the effects of chromium exposure on the formation of 8-hydroxydeoxyguanosine(8-OH-dG) and sister chromatid exchanges(SCEs) frequency in... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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- The Synergism between Belotecan and Cisplatin in Gastric Cancer
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Jung JY, Song SH, Kim TY, Park JH, Jong HS, Im SA, Kim TY, Bang YJ, Kim NK
- KMID: 2166061
- Cancer Res Treat.
- 2006 Jun;38(3):159-167.
PURPOSE: We wanted to demonstrate the anti-cancer effect and interaction between belotecan and cisplatin on gastric cancer cell line and we evaluated the mechanisms of this synergistic effect in vitro.... -
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- Site-Specific Mutagenesis in Human Cells by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives
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Moon KY
- KMID: 2127916
- Cancer Res Treat.
- 2004 Apr;36(2):151-156.
PURPOSE: 7-Bromomethylbenz[a]anthracene is a well- known mutagen and carcinogen. The aim of this study is to determine the mutagenic potency of its two major DNA adducts [N2-(benz[a]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[a]a2G) and N6-(benz[a]anthracen-7-... -
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- Suppressed DNA Repair Mechanisms in Rheumatoid Arthritis
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Lee SH, Firestein
- KMID: 1974519
- Immune Netw.
- 2002 Dec;2(4):208-216.
- doi: 10.4110/in.2002.2.4.208
BACKGROUND: Reactive oxygen and nitrogen are produced by rheumatoid arthritis (RA) synovial tissue and can induce mutations in key genes. Normally, this process is prevented by a DNA mismatch repair... -
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- Increased ERCC Expression Correlates with Improved Outcome of Patients Treated with Cisplatin as an Adjuvant Therapy for Curatively Resected Gastric Cancer
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Baek SK, Kim SY, Lee JJ, Kim YW, Yoon HJ, Cho KS
- KMID: 2166088
- Cancer Res Treat.
- 2006 Feb;38(1):19-24.
PURPOSE: It has been reported that the overexpression of the excision repair cross-complementing 1 (ERCC1) gene, which is essential for the repair of cisplatin (CDDP)- DNA adducts, negatively influences the... -
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