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Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells

Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC

  • KMID: 927133
  • Exp Mol Med.
  • 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and...
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Hypermethylation of the RUNX3 gene in hepatocellular carcinoma

Park WS, Cho YG, Kim CJ, Song JH, Lee YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY

  • KMID: 1093462
  • Exp Mol Med.
  • 2005 Aug;37(4):276-281.
Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. Recently, RUNX3 gene, one of TGF-beta-Smads signaling transduction pathway genes, showed strong tumor-suppressor...
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