- Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes
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Han KM, Ahn SY, Seo H, Yun J, Cha HJ, Shin JS, Kim YH, Kim H, Park HK, Lee YM
- KMID: 2378807
- Biomol Ther.
- 2017 May;25(3):288-295.
- doi: 10.4062/biomolther.2016.153
The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and... -
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- Extremely Elevated International Normalized Ratio of Warfarin in a Patient with CYP2C9*1/*3 and Thyrotoxicosis
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Lee JE, Ryu DH, Jeong HJ, Kim JH, Jun JE, Kim JS, Lee SY
- KMID: 1794613
- J Korean Med Sci.
- 2014 Sep;29(9):1317-1319.
- doi: 10.3346/jkms.2014.29.9.1317
A 73-yr-old Korean man with permanent atrial fibrillation visited outpatient clinic with severely increased International Normalized Ratio (INR) values after taking a usual starting dosage of warfarin to prevent thromboembolism.... -
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- Development and Comparison of Warfarin Dosing Algorithms in Stroke Patients
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Cho SM, Lee KY, Choi JR, Lee KA
- KMID: 2374082
- Yonsei Med J.
- 2016 May;57(3):635-640.
- doi: 10.3349/ymj.2016.57.3.635
PURPOSE: The genes for cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) have been identified as important genetic determinants of warfarin dosing and have been... -
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- Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines Part 2
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Kim S, Yun YM, Kim IS, Song SH, Woo HI, Lee KA, Lee W, Cho HJ, Ji M, Chae HJ, Lee SY, Chun S
- KMID: 2353421
- Lab Med Online.
- 2016 Oct;6(4):193-213.
- doi: 10.3343/lmo.2016.6.4.193
Pharmacogenetics is a rapidly evolving field and the number of pharmacogenetic tests for clinical use is steadily increasing. However, incorrect or inadequate implementation of pharmacogenetic tests in clinical practice may... -
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- Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines
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Kim S, Yun YM, Chae HJ, Cho HJ, Ji M, Kim IS, Wee KA, Lee W, Song SH, Woo HI, Lee SY, Chun S
- KMID: 2373642
- Ann Lab Med.
- 2017 Mar;37(2):180-193.
- doi: 10.3343/alm.2017.37.2.180
Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended... -
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- Screening study for genetic polymorphisms affecting pharmacokinetics of talniflumate
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Jin LH, Kim BH, Lee JH, Lee K, Kwack K, Yim SV
- KMID: 2406997
- Transl Clin Pharmacol.
- 2017 Dec;25(4):166-172.
- doi: 10.12793/tcp.2017.25.4.166
Talniflumate is a phthalidyl ester of niflumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis. To screen the... -
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