- A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity
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Song M, Do H, Kwon OK, Yang EJ, Bae JS, Jeong TC, Song KS, Lee S
- KMID: 2170656
- Biomol Ther.
- 2014 Mar;22(2):155-160.
Thelephoric acid is an antioxidant produced by the hydrolysis of polyozellin, which is isolated from Polyozellus multiplex. In the present study, the inhibitory effects of polyozellin and thelephoric acid on... -
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- Association of the polymorphisms in CYP1A1 and CYP1A2 genes with preterm premature rupture of membranes
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Park CH, Shin JC, Yang DE, Park IY, Ko HS, Kim YH, Ahn HY, Kim SJ, Kim SP
- KMID: 2272461
- Korean J Obstet Gynecol.
- 2004 Dec;47(12):2319-2324.
OBJECTIVE: Preterm delivery (PTD) is the leading cause of perinatal mortality and morbidity. However, its etiology and pathogenesis remain unknown in most cases. Recently, some research put forth the hypothesis... -
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- CYP1A2 polymorphism and theophylline clearance in Korean non-smoking asthmatics
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Yim EY, Kang HR, Jung JW, Sohn SW, Cho SH
- KMID: 2397300
- Asia Pac Allergy.
- 2013 Oct;3(4):231-240.
- doi: 10.5415/apallergy.2013.3.4.231
BACKGROUND: Theophylline is mainly metabolized by cytochrome P450 (CYP) 1A2 and CYP2E1 which show inter-individual variations. However, the underlying mechanism remains unknown in humans. We investigated the relationship between differences... -
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- The Association of Neonatal Hyperbilirubinemia with UGT1A1 and CYP1A2 Gene Polymorphism in Korean Neonates
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Kang H, Lim JH, Kim JS, Kim ER, Kim SD, Lee HJ, Chung JH
- KMID: 2278673
- Korean J Pediatr.
- 2005 Apr;48(4):380-386.
PURPOSE: The incidence of nonphysiologic neonatal hyperbilirubinemia is twice as high in East Asians as in whites. Recently, UGT1A1 mutation was found to be a risk factor for neonatal hyperbilirubinemia.... -
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- Constitutive expression and changes of cytochrome P450 isozymes mRNAs by vehicles (petrolatum, DMSO, ethanol) in rat skin using semi-quantitative RT-PCR
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Lee AY, Lee KH, Ko DS, Chey WY
- KMID: 1607080
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):407-412.
Many drugs are primarily metabolized by the cytochrome P450s (CYPs). Drug metabolites would be important allergens for adverse drug reactions such as drug eruptions. Skin tests with a suspected drug have conducted to... -
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- SNP genetic polymorphisms of MDR-1, CYP1A2 and CYPB11 genes in four canine breeds upon toxicological evaluation
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Gagliardi , Llambi S, Arruga MV
- KMID: 2344299
- J Vet Sci.
- 2015 Sep;16(3):273-280.
- doi: 10.4142/jvs.2015.16.3.273
The fields of pharmacogenetics and pharmacogenomics have become increasingly promising regarding the clinical application of genetic data to aid in prevention of adverse reactions. Specific screening tests can predict which... -
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- The Inhibitory Effect of the Second Generation Sulfonylurea Drugs on Cytochrome P450-catalyzed Reaction by Human Liver Microsomes
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Choi JY, Kim SY, Kim KA, Park JY
- KMID: 2199993
- J Korean Soc Endocrinol.
- 2002 Aug;17(4):544-553.
BACKGROUND: Sulfonylurea drugs have been used for many decades as one of the main families of drugs for the treatment of type 2 diabetes mellitus. Even though there are many... -
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- CYP1A2 activity as a risk factor for bladder cancer
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Lee SW, Jang IJ, Shin SG, Lee KH, Yim DS, Kim SW, Oh SJ, Lee SH
- KMID: 644840
- J Korean Med Sci.
- 1994 Dec;9(6):482-489.
- doi: 10.3346/jkms.1994.9.6.482
CYP1A2, CYP2D6 and N-acetyltransferase activities were estimated in 100 patients with bladder cancer and 84 control subjects from measurements of theophylline, metoprolol and isoniazid and their metabolites in urine, respectively.... -
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- Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor
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Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C, Gao Y
- KMID: 2375041
- Biomol Ther.
- 2017 Mar;25(2):202-212.
- doi: 10.4062/biomolther.2016.066
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent... -
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- Functional Comparison of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells as Sources of Hepatocyte-Like Cells
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Jeong J, Kim KN, Chung MS, Kim HJ
- KMID: 2360886
- Tissue Eng Regen Med.
- 2016 Dec;13(6):740-749.
- doi: 10.1007/s13770-016-0094-y
Pluripotent stem cells can differentiate into many cell types including mature hepatocytes, and can be used in the development of new drugs, treatment of diseases, and in basic research. In... -
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- Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay
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Kim YH, Bae YJ, Kim HS, Cha HJ, Yun JS, Shin JS, Seong WK, Lee YM, Han KM
- KMID: 2380299
- Biomol Ther.
- 2015 Sep;23(5):486-492.
- doi: 10.4062/biomolther.2015.041
Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA... -
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- Metabolic Drug Interactions in the Polypharmacy of Mood Disorders
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Moon E, Chang JS, Ha TH, Ha K
- KMID: 2287409
- Korean J Psychopharmacol.
- 2008 Dec;19(6):307-322.
Polypharmacy has recently become usual practice in the treatment of patients with mood disorders. In this article, we review the results of recent studies on metabolic drug interactions between anticonvulsants,... -
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- Assessment of flavin-containing monooxygenase (FMO) activity by determining urinary ratio of theobromine and caffeine in a Korean population after drinking a cup of coffee
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Chung WG, Kang JH, Roh HK, Lee KH, Park CS, Cha YN
- KMID: 1554144
- Korean J Physiol Pharmacol.
- 1999 Apr;3(2):207-213.
To examine individual variation in drug metabolism catalyzed by flavin-containing monooxygenase (FMO), 179 Korean volunteers' urinary molar concentration ratio of theobromine (TB) and caffeine (CA) was determined. Their urine was collected for 1... -
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- Functional Significance of Cytochrome P450 1A2 Allelic Variants, P450 1A2*8, *15, and *16 (R456H, P42R, and R377Q)
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Lim YR, Kim IH, Han S, Park HG, Ko MJ, Chun YJ, Yun CH, Kim D
- KMID: 2380353
- Biomol Ther.
- 2015 Mar;23(2):189-194.
- doi: 10.4062/biomolther.2015.009
P450 1A2 is responsible for the metabolism of clinically important drugs and the metabolic activation of environmental chemicals. Genetic variations of P450 1A2 can influence its ability to perform these... -
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- Pharmacologic Treatment of Restless Legs Syndrome
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Kim SW, Jang JE, Kim SY, Kim JM, Shin IS, Yang SJ, Yoon JS
- KMID: 2287443
- Korean J Psychopharmacol.
- 2010 Jan;21(1):14-21.
Restless legs syndrome (RLS) is defined as the urge to move one's legs, accompanied by unpleasant sensations in one's limbs, and is typically more severe at night. Sleep hygiene measures... -
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