- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
-
Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
- CITED
-
- Close
- SHARE
-
- Close
- Enhanced expression of cathepsin L in metastatic bone tumors
-
Park IC, Lee SY, Jeon DG, Lee JS, Hwang CS, Hwang YG, Lee SH, Hong WS, Hong SI
- KMID: 644942
- J Korean Med Sci.
- 1996 Apr;11(2):144-148.
- doi: 10.3346/jkms.1996.11.2.144
Cathepsin L is a kind of cystein proteases which are known to facilitate the invasion and metastasis of tumor cells by degrading the components of basement membrane and extracellular matrix.... -
- CITED
-
- Close
- SHARE
-
- Close
