- COX-2 Inhibitors in Inflammatory Bowel Disease: Friends or Foes?
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Park YS
- KMID: 937929
- Korean J Gastroenterol.
- 2007 Dec;50(6):350-355.
The cyclooxygenase (COX) is a key enzyme in the coversion of arachidonic acid to prostaglandins. COX-1 is constitutively expressed and is a critical housekeeping gene, whereas COX-2 is rapidly upregulated... -
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- AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin
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Lee YK, Park SY, Kim YM, Lee WS, Park OJ
- KMID: 1123467
- Exp Mol Med.
- 2009 Mar;41(3):201-207.
- doi: 10.3858/emm.2009.41.3.023
AMPK (AMP-activated protein kinase) is highly conserved in eukaryotes, where it functions primarily as a sensor of cellular energy status. Recent studies indicate that AMPK activation strongly suppresses cell proliferation... -
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- Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
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Lee EJ, Choi EM, Kim SR, Park JH, Kim H, Ha KS, Kim YM, Kim SS, Choe M, Kim JI, Han JA
- KMID: 756069
- Exp Mol Med.
- 2007 Aug;39(4):469-476.
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in... -
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