- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
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Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
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