- New Inotropic Agent-Levosimendan
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Choi IC
- KMID: 2034385
- Korean J Anesthesiol.
- 2006 Nov;51(5):519-527.
- doi: 10.4097/kjae.2006.51.5.519
Several clinical studies suggest substantial limitations of currently available positive inotropic substances, including beta1-adrenoceptor agonists and phosphodiesterase III inhibitors. Levosimendan, a myofilament calcium sensitizer with inotropic effects, increases myocardial performance... -
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- Successful Opening of Ductus Arteriosus with Milrinone in a Newborn with Tetralogy of Fallot and Pulmonary Atresia
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Won CB, Kim MY, Choi DY, Cho HJ, Shim SY, Son DW
- KMID: 2099214
- J Korean Soc Neonatol.
- 2011 Nov;18(2):365-369.
- doi: 10.5385/jksn.2011.18.2.365
Tetralogy of Fallot (TOF) assumes its' most severe form when accompanied by pulmonary atresia (PA). Preserving the patent ductus arteriosus to maintain pulmonary blood flow is life-saving for patients with... -
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- The Clinical Effects of Cilostazol on Atherosclerotic Vascular Disease
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Park JS, Kim YJ
- KMID: 1776343
- Korean Circ J.
- 2008 Sep;38(9):441-445.
- doi: 10.4070/kcj.2008.38.9.441
Cilostazol inhibits phosphodiesterase III (PDE III), which is predominantly distributed to and regulates physiologic responses in platelets, cardiac muscle cells, vascular smooth muscle cells, and adipose cells. Clinically, it is... -
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- Phosphodiesterase 4D Gene and Risk of Noncardiogenic Ischemic Stroke in a Korean Population
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Kim MK, Kim JT, Choi SM, Lee SH, Park MS, Cho KH
- KMID: 1779135
- J Korean Med Sci.
- 2009 Apr;24(2):307-310.
- doi: 10.3346/jkms.2009.24.2.307
Recently published studies from different populations provide apparently conflicting evidence on the association between the phosphodiesterase 4D (PDE4D) gene and ischemic stroke. The relationship between a representative PDE4D genotype and... -
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- Development of acute myocardial infarction in a young female patient with essential thrombocythemia treated with anagrelide: a case report
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Lim YH, Lee YY, Kim JH, Shin J, Lee JU, Kim KS, Kim SK, Kim JH, Lim HK
- KMID: 2083548
- Korean J Hematol.
- 2010 Jun;45(2):136-138.
- doi: 10.5045/kjh.2010.45.2.136
Essential thrombocythemia (ET) is a chronic myeloproliferative disorder with a prolonged clinical course. Since this disorder is considered to be at increased risk of thromboembolism, therapy is mainly focused on... -
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- Cilostazol Reduces PAC-1 Expression on Platelets in Ischemic Stroke
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Lee SY, Kang MJ, Cha JK
- KMID: 2287667
- J Clin Neurol.
- 2008 Dec;4(4):148-152.
- doi: 10.3988/jcn.2008.4.4.148
BACKGROUND AND PURPOSE: Cilostazol, a phosphodiesterase III inhibitor, is known to be a useful antiplatelet agent that inhibits the progression of atherosclerosis in ischemic stroke. This study investigated the effects... -
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- Does Milrinone Improve Hemodynamic Variables in Patients with Pulmonary Hypertension Due to Valvular Heart Disease?
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Shim YH, Oh YJ, Nam SB, Kim E, Hong YW, Kwak YL
- KMID: 1935992
- Korean J Anesthesiol.
- 2003 Feb;44(2):187-192.
- doi: 10.4097/kjae.2003.44.2.187
BACKGROUND: Milrinone is a bipyridine phosphodiesterase III inhibitor that exerts both positive inotropic and direct vasodilatory effects. The efficacy and safety of intravenous milrinone in heart failure has been evaluated... -
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- Effect of Amrinone, a Selective Inhibitor of Phosphodiesterase III, on PMNs-induced Cardiac Dysfunction in Ischemia/reperfusion
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Oh BK, Kim HK, Choi SR, Song JH, Park ES, Choi BS, Park JD, Shin YK
- KMID: 1517036
- Korean J Physiol Pharmacol.
- 2004 Feb;8(1):43-50.
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Amrinone, a specific inhibitor of phosphodiesterase 3, has an antioxidant activity against... -
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- The vasorelaxatory effect of the milrinone on the preconstricted rat aorta
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Kwon HU, Park JT, Ryoo S, Park IH, Lee SH, Kim SY, Yoon SH, Lim HK
- KMID: 2092249
- Korean J Anesthesiol.
- 2009 Nov;57(5):615-621.
- doi: 10.4097/kjae.2009.57.5.615
BACKGROUND: Milrinone, phosphodiesterase III inhibitor, has been used effectively in patients with right heart failure, especially resulted from pulmonary hypertension. However, milrinone is often used with alpha- and beta-adrenergic receptor... -
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- The Combined Effect of Desflurane and Milrinone on the Function of the Isolated Rat Heart
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Yoon JR, Kong MH, Kim KN, Lee IO, Lee MK, Lim SH, Choi YS, Kim NS
- KMID: 2299017
- Korean J Anesthesiol.
- 2003 Mar;44(3):393-403.
- doi: 10.4097/kjae.2003.44.3.393
BACKGROUND: Desflurane depresses the contractile function of the myocardium. It also causes direct coronary vasodilation. Milrinone, a phosphodiesterase III inhibitor, usually increases myocardial contractility and also has vasodilatory activity. Some... -
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- Clinical Effects of Additional Cilostazol Administration After Drug-Eluting Stent Insertion
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Kum DS, Kim MH, Paik JH, Yu LH, Han J, Kim KH, Park TH, Cha KS, Kim YD, Quan ML, Han JY
- KMID: 1769509
- Korean Circ J.
- 2009 Jan;39(1):21-25.
- doi: 10.4070/kcj.2009.39.1.21
BACKGROUND AND OBJECTIVES: Cilostazol, a selective inhibitor of phosphodiesterase III (PDE III), prevents inactivation of the intracellular second messenger cyclic adenosine monophosphate (cAMP) and irreversibly inhibits platelet aggregation and vasodilation.... -
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