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Effect of ginsenosides in a mouse model of bone cancer pain

Yoon MH, Lee HG, Kim WM, Ju J, Kim YO, Cui JH

  • KMID: 1803583
  • Anesth Pain Med.
  • 2010 Oct;5(4):321-324.
BACKGROUND: Ginsenosides have been used for a long time as an oriental folk medicine. Although ginsenosides modulate the nociceptive transmission, the effect of ginsenosides on a bone cancer pain has...
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The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Intrathecal Zaprinast in the Formalin Test of Rats

Yoon SJ, Kim YO, Huang LJ, Cui JH, Heo BH, Jeong ST, Yoon MH

BACKGROUND: Spinal zaprinast, phospodiesterase inhibitor, has been shown to have an antinociception through an increase of cGMP. The aim of this study was to examine the role of spinal adrenergic...
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The Role of the Pelvis in Sagittal Alignment of Lumbar Degenerative Disease Patients

Kim YC, You KH, Jang C, Cui JH, Wilartratsami S, Kim TH, Oh JK, Park MS, Kim SW

STUDY DESIGN: Literature review. OBJECTIVES: To present updated information on the relationship of the pelvis and lumbar degenerative disease (LDD) patients and to emphasize the importance of the pelvis in sagittal...
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The Role of Opioid Receptor on the Analgesic Action of Intrathecal Sildenafil in Rats

Lee HG, Jeong CY, Yoon MH, Kim WM, Shin SH, Kim YO, Huang LJ, Cui JH

BACKGROUND: Intrathecal sildenafil has produced antinociception by increasing the cGMP through inhibition of phosphodiesterase 5. Spinal opioid receptor has been reported to be involved in the modulation of nociceptive transmission....
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GABAB Receptor Modulation on the Antinociception of Intrathecal Sildenafil in the Rat Formalin Test

Kim WM, Yoon MH, Lee HG, Han YG, Kim YO, Huang LJ, Cui JH

BACKGROUND: A phosphodiesterase 5 inhibitor, sildenafil, has been effective against nociception. Several lines of evidence have demonstrated the role of the GABAergic pathway in the modulation of nociception. The impact...
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The effect of inducing morphine tolerance on anti-allodynic action of gabapentin in spinal nerve-ligated rat

Cui JH, Lee HG, Kim WM, Bae HB, Yoon MH, Choi JI

BACKGROUND: Morphine is more effective in inflammatory or acute pain than neuropathic pain. Recently, some reports demonstrated that the development and maintenance of opioid tolerance and neuropathic pain have similar...
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The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Korean Red Ginseng in the Spinal Cord of Rats

Kim SY, Yoon MH, Lee HG, Kim WM, Lee JD, Kim YO, Huang LJ, Cui JH

BACKGROUND: Experimental evidence indicates that ginseng modulate the nociceptive transmission. Authors examined the role of adrenergic and cholinergic receptors on the antinociceptive action of Korean red ginseng against the formalin-induced...
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The role of group III metabotropic receptors on opioid tolerance

Yoon MH, Lee HK, Kim WM, Cho SY, Kim YO, Cui JH

  • KMID: 1970958
  • Anesth Pain Med.
  • 2009 Apr;4(2):138-141.
BACKGROUND: Prolonged exposure to morphine causes tolerance to morphine-induced antinociception, yet the mechanisms of such tolerance are not fully understood. Although group I and II metabolic glutamate receptors (mGluRs) are...
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Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil

Kim WM, Yoon MH, Cui JH

Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium...
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The Effect of Treatment with Intrathecal Ginsenosides in a Rat Model of Postoperative Pain

Shin DJ, Yoon MH, Lee HG, Kim WM, Park BY, Kim YO, Huang LJ, Cui JH

BACKGROUND: Ginseng has been used to manage various types of pain in folk medicine. This study characterized the effect of treatment with intrathecal ginsenosides, the active components of ginseng in...
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