- Effects of CpG Oligodeoxynucleotide on Airway Inflammation after Topical Application of and Airway Challenge with Dermatophagoides farinae in NC/Nga Mice
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- KMID: 2299515
- Korean J Asthma Allergy Clin Immunol.
- 2011 Jun;31(2):131-139.
BACKGROUND: Atopic dermatitis (AD) is the initial step of allergic march that progresses to airway allergic disease. There has been much interest in the interruption of the allergic march, but... -
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- Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression
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Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH
- KMID: 964666
- Exp Mol Med.
- 2010 Oct;42(10):712-720.
- doi: 10.3858/emm.2010.42.10.070
Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum... -
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- Effect of Cytosine-phosphate-Guanine Oligodeoxynucleotides on Airway Hyperresponsiveness and Inflammation of Repeated Respiratory Syncytial Virus Infection in a Mouse Model
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- KMID: 2146024
- Korean J Asthma Allergy Clin Immunol.
- 2010 Jun;30(2):123-130.
BACKGROUND: Severe respiratory syncytial virus (RSV) infection in neonate has been reported as a risk factor for the development of allergic asthma or early transient wheezing. RSV can induce reinfection... -
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- Limited Effect of CpG ODN in Preventing Type 1 Diabetes in NOD Mice
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Lee BJ, Kim SK, Kim MK, Park ES, Cho HC, Shim MS, Kim MJ, Shin YG, Chung CH
- KMID: 1734067
- Yonsei Med J.
- 2005 Jun;46(3):341-346.
- doi: 10.3349/ymj.2005.46.3.341
Type 1 diabetes is considered as Th1 cell mediated autoimmune disease and the suppression of Th1 cells or the activation of Th2 cells has been regarded as a plausible immunologic... -
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- Effect of Mouse Type and Human Type of CpG Oligonucleotide Vaccination on Development of Diabetes in NOD Mice
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Lee BJ, Kim SK, Park ES, Jang HJ, Cho HC, Shim MS, Kim MJ, Shin YG, Chung CH
- KMID: 2008287
- J Korean Diabetes Assoc.
- 2002 Dec;26(6):451-459.
BACKGROUND: Type 1 diabetes is autoimmune disease and the modulation of immune system could offer breakthrough to the disease. Unmethylated CpG motifs and their oligoneucleotide are potent immunostimulators that can... -
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- Modulation of Eosinophilia and Cytokines of Bronchoalveolar Larvage Fluid(BALF) by CpG Oligodeoxynucleotides(ODN) in a Mouse Model of Established Airway Inflammation
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Mok JS, Choi SM
- KMID: 1994329
- Pediatr Allergy Respir Dis.
- 2002 Jun;12(2):93-104.
PURPOSE: Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. Oligodeoxynucleotides containing a CpG motif(CpG ODN), as potent inducers of... -
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