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Effects of CpG Oligodeoxynucleotide on Airway Inflammation after Topical Application of and Airway Challenge with Dermatophagoides farinae in NC/Nga Mice

  • KMID: 2299515
  • Korean J Asthma Allergy Clin Immunol.
  • 2011 Jun;31(2):131-139.
BACKGROUND: Atopic dermatitis (AD) is the initial step of allergic march that progresses to airway allergic disease. There has been much interest in the interruption of the allergic march, but...
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Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression

Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH

Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum...
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Effect of Cytosine-phosphate-Guanine Oligodeoxynucleotides on Airway Hyperresponsiveness and Inflammation of Repeated Respiratory Syncytial Virus Infection in a Mouse Model

  • KMID: 2146024
  • Korean J Asthma Allergy Clin Immunol.
  • 2010 Jun;30(2):123-130.
BACKGROUND: Severe respiratory syncytial virus (RSV) infection in neonate has been reported as a risk factor for the development of allergic asthma or early transient wheezing. RSV can induce reinfection...
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Limited Effect of CpG ODN in Preventing Type 1 Diabetes in NOD Mice

Lee BJ, Kim SK, Kim MK, Park ES, Cho HC, Shim MS, Kim MJ, Shin YG, Chung CH

Type 1 diabetes is considered as Th1 cell mediated autoimmune disease and the suppression of Th1 cells or the activation of Th2 cells has been regarded as a plausible immunologic...
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Effect of Mouse Type and Human Type of CpG Oligonucleotide Vaccination on Development of Diabetes in NOD Mice

Lee BJ, Kim SK, Park ES, Jang HJ, Cho HC, Shim MS, Kim MJ, Shin YG, Chung CH

  • KMID: 2008287
  • J Korean Diabetes Assoc.
  • 2002 Dec;26(6):451-459.
BACKGROUND: Type 1 diabetes is autoimmune disease and the modulation of immune system could offer breakthrough to the disease. Unmethylated CpG motifs and their oligoneucleotide are potent immunostimulators that can...
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Modulation of Eosinophilia and Cytokines of Bronchoalveolar Larvage Fluid(BALF) by CpG Oligodeoxynucleotides(ODN) in a Mouse Model of Established Airway Inflammation

Mok JS, Choi SM

  • KMID: 1994329
  • Pediatr Allergy Respir Dis.
  • 2002 Jun;12(2):93-104.
PURPOSE: Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. Oligodeoxynucleotides containing a CpG motif(CpG ODN), as potent inducers of...
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