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Established and Emerging Therapies in Acute Spinal Cord Injury

Gadot R, Smith DN, Prablek M, Grochmal JK, Fuentes A, Ropper AE

Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and...
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The Role of Alginate Hydrogels as a Potential Treatment Modality for Spinal Cord Injury: A Comprehensive Review of the Literature

Jarrah R, Sammak SE, Onyedimma C, Ghaith AK, Moinuddin F, Bhandarkar AR, Siddiqui A, Madigan N, Bydon M

Objective: To comprehensively characterize the utilization of alginate hydrogels as an alternative treatment modality for spinal cord injury (SCI). Methods: An extensive review of the published literature on studies using alginate...
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Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature

Lee S, Cho DC, Han I, Kim KT

Curcumin is a polyphenolic chemical derived from the rhizomes of Curcuma longa. It has been used throughout the Indian subcontinent for medicinal purposes, religious events, and regional cuisine. It has...
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Alendronate Enhances Functional Recovery after Spinal Cord Injury

Choi Y, Shin T

Spinal cord injury is a destructive disease characterized by motor/sensory dysfunction and severe inflammation. Alendronate is an anti-inflammatory molecule and may therefore be of benefit in the treatment of the...
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The Video-Urodynamic and Electrophysiological Characteristics in Patients With Traumatic Spinal Cord Injury

Wang Z, Deng H, Li X, Liao L

Purpose: To investigate the video-urodynamic and pelvic floor electrophysiological characteristics in patients with traumatic spinal cord injury (SCI). Methods: This retrospective reviewed the clinical records, urodynamic and pelvic floor electrophysiological data...
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Efficacy of Electrical Stimulation-Augmented Virtual Reality Training in Improving Balance in Individuals with Incomplete Spinal Cord Injury: Study Protocol of a Randomized Controlled Trial

Walia S, Kumar P, Kataria C

Study Design: This study is a single-blind, parallel, three-group, and randomized controlled trial. Purpose: This study aimed to investigate the effectiveness of electrical stimulation-augmented virtual reality training in improving balance in...
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Thirty-Six-Month Follow-up of Diaphragm Pacing with Phrenic Nerve Stimulation for Ventilator Dependence in Traumatic Tetraplegia: The Way Forward for Spinal Cord Injury Rehabilitation in a Developing Country

Sharma V, Jafri H, Roy N, Dangi M, Kataruka M

Respiratory failure and chronic ventilator dependence in tetraplegics following cervical injuries located high on the spine (C1–C3) constitute significant challenges in the rehabilitation of patients given the occurrence of repeated...
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Traumatic Spinal Injury Associated with All-Terrain Vehicle (ATV) Accidents: A 10-Year Retrospective Analysis of the Coachella Valley

Fiani B, Houston R, Cathel A, Pennington E, Siddiqi I, Arshad M, Soula M, Jenkins R

Objective: The use of all-terrain vehicles (ATVs) and associated injuries have significantly increased in the last decade. This study aimed to determine the frequency of ATV-associated spinal cord injuries (SCIs)...
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An Atypical Choroid Plexus Papilloma Initially Manifestating as Radicular Symptoms

Lee CJ, Kim JH, Kim Y, Lee JB, Ryu B

A 29-year-old woman had 1-month history of back pain radiating into lower extremities, motor weakness, and sensory abnormalities in both lower extremities. Contrast-enhanced spinal magnetic resonance imaging (MRI) revealed a...
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Novel Methods of Necroptosis Inhibition for Spinal Cord Injury Using Translational Research to Limit Secondary Injury and Enhance Endogenous Repair and Regeneration

Fiani B, Kondilis A, Soula M, Tao A, Alvi MA

Spinal cord injuries (SCIs) pose an immense challenge from a clinical perspective as current treatments and interventions have been found to provide marginal improvements in clinical outcome (with varying degrees...
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Effects of Wearable Powered Exoskeletal Training on Functional Mobility, Physiological Health and Quality of Life in Non-ambulatory Spinal Cord Injury Patients

Kim HS, Park JH, Lee HS, Lee JY, Jung JW, Park SB, Hyun DJ, Park S, Yoon J, Lim H, Choi YY, Kim MJ

Background: Spinal cord injury (SCI) is a serious clinical condition that impacts a patient's physical, psychological, and socio-economic status. The aim of this pilot study was to evaluate the effects...
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Hemodynamic Management of Acute Spinal Cord Injury: A Literature Review

Lee YS, Kim KT, Kwon BK

The goal of acute spinal cord injury (SCI) management is to reduce secondary injuries and improve neurological recovery after its occurrence. This review aimed to explore the literature regarding hemodynamic...
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Rehabilitation of Spinal Cord Injury: WFNS Spine Committee Recommendations

Peev N, Komarov A, Osorio-Fonseca E, Zileli M

Spinal cord injury (SCI) is accompanied by a significant number of complications associated with damage to the spinal cord, gross functional impairments leading to limited self-care and movement, leading to...
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Outcomes of Spinal Cord Injury: WFNS Spine Committee Recommendations

Parthiban J, Zileli M, Sharif SY

This comprehensive review article aims to provide some definitive statements on the factors like clinical syndromes, radiological findings, and decompressive surgery, that may influence the outcomes in cervical spinal cord...
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Pediatric Cervical Spine Injuries and SCIWORA: WFNS Spine Committee Recommendations

Konovalov N, Peev N, Zileli M, Sharif S, Kaprovoy S, Timonin S

Cervical trauma in children have variations from the adults mainly due to anatomic differences. An optimal diagnostic and treatment strategy is critical, particularly when there is a lack of standardized...
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Pharmacologic and Regenerative Cell Therapy for Spinal Cord Injury: WFNS Spine Committee Recommendations

Takami T, Shimokawa N, Parthiban J, Zileli M, Ali S

This is a review article examining the pharmacologic and regenerative cell therapy for spinal cord injury. A literature search during last 10 years were conducted using key words. Case reports,...
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Assisted Breathing with a Diaphragm Pacing System: A Systematic Review

Woo Al, Tchoe Hj, Shin Hw, Shin Cm, Lim CM

Purpose: Patients with respiratory failure associated with neurological dysfunction often require mechanical ventilator support, which poses increased economic burden and ventilator-associated complications. A diaphragm pacing system (DPS) is an implanted...
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Evaluation of PTEN Inhibitor Following Spinal Cord Injury on Recovery of Voiding Efficiency and Motor Function Observed by Regeneration in Spinal Cord

Cho YS, Kim SJ, Kim KH

Purpose: Neurogenic bladder (NB) associated with spinal cord injury (SCI) is a serious health problem. However, no effective treatment has been developed for SCI patients with NB. Phosphatase and tensin...
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Upper Limb Reconstruction in Tetraplegic Patients: A Primer for Spinal Cord Injury Specialists

Liew SK, Shim BJ, Gong HS

Cervical spinal cord injury (SCI) often causes debilitating loss of function of the upper limb. Upper extremity reconstruction surgery can restore some of the upper limb function in tetraplegic patients...
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Prevention and treatment of pressure sore following spinal cord injury

Kim MO

Pressure sores or pressure injury is a serious complication of a spinal cord injury (SCI), representing a challenging problem for patients, their caregivers, and their physicians. Persons with SCI are...
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