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Evaluation of immunocontraceptive vaccine composed of gonadotropin-releasing hormone conjugated with granulocyte-macrophage colony-stimulating factor in male rats

Park BJ, Kim YH, Ahn HS, Han SH, Go HJ, Lee JB, Park SY, Song CS, Lee SW, Choi IS

Surgical castration performed to reduce male-associated problems results in pain and microbial infections in male animals. Therefore, immunocontraception, which is mediated by the animal's own antibodies against reproductive hormones, has...
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Human spermatozoa anti-proprotein convertase subtilisin/kexin type 4 synthesis using New Zealand rabbit for novel immunocontraception in males

Dahril , Aulanni'am , Keumala V, Mustafa A

PURPOSE: Proprotein convertase subtilisin/kexin type 4 (PCSK4, a 54-kDa protease) is expressed in the plasma membrane of the acrosome in human spermatozoa. It plays a critical role in penetrating the...
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Evaluation of infertility efficacy of the E. coli expressed STF2-GnRH vaccine in male cats

Lee YJ, Jo EJ, Lee HW, Hwang BR, Kim YH, Park BJ, Cho YJ, Lee YA, Choi IS, Han JS

Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus and anti-GnRH antibodies are not formed under normal conditions. However, administration an excess of recombinant GnRH protein results in the formation of...
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Induction of castration by immunization of male dogs with recombinant gonadotropin-releasing hormone (GnRH)-canine distemper virus (CDV) T helper cell epitope p35

Jung MJ, Moon YC, Cho IH, Yeh JY, Kim SE, Chang WS, Park SY, Song CS, Kim HY, Park KK, McOrist S, Choi IS, Lee JB

  • KMID: 1106070
  • J Vet Sci.
  • 2005 Mar;6(1):21-24.
Immunocastration is a considerable alternative to a surgical castration method especially in male animal species for alleviating unwanted male behaviors and characteristics. Induction of high titer of antibody specific for...
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