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Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction

Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM

The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide...
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Mutations in GJB2 as Major Causes of Autosomal Recessive Non-Syndromic Hearing Loss: First Report of c.299-300delAT Mutation in Kurdish Population of Iran

Azadegan-Dehkordi F, Bahrami T, Shirzad M, Karbasi G, Yazdanpanahi N, Farrokhi E, Koohiyan M, Tabatabaiefar MA, Hashemzadeh-Chaleshtori M

BACKGROUND AND OBJECTIVES: Autosomal recessive non-syndromic hearing loss (ARNSHL) with genetic origin is common (1/2000 births). ARNSHL can be associated with mutations in gap junction protein beta 2 (GJB2). To...
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X-linked Charcot-Marie-Tooth disease case with a novel missense mutation in GJB1 gene

Lee JM, Shin JH

X-linked Charcot-Marie-Tooth disease type 1 (CMTX1) is caused by the mutation in GJB1 gene, characterized by the transient central nervous system involvement and long standing peripheral polyneuropathy which does not...
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Long Term Speech Perception Outcomes of Cochlear Implantation in Gap Junction Protein Beta 2 Related Hearing Loss

Kim SH, Nepali R, Yoo MH, Lee KS, Chung JW

BACKGROUND AND OBJECTIVES: The mutation of the gap junction protein beta 2 (GJB2) gene is the predominant cause of autosomal recessive non-syndromic hearing loss. The purpose of this study was...
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High-fat Diet Accelerates Intestinal Tumorigenesis Through Disrupting Intestinal Cell Membrane Integrity

Park MY, Kim MY, Seo YR, Kim JS, Sung MK

BACKGROUND: Excess energy supply induces chronic low-grade inflammation in association with oxidative stress in various tissues including intestinal epithelium. The objective of this study was to investigate the effect of...
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Type 2 Diabetes Induces Prolonged P-wave Duration without Left Atrial Enlargement

Li B, Pan Y, Li X

Prolonged P-wave duration has been observed in diabetes. However, the underlying mechanisms remain unclear. The aim of this study was to elucidate the possible mechanisms. A rat model of type...
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Non-syndromic hearing loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 (Connexin 26) gene

Kim J, Jung J, Lee MG, Choi JY, Lee KA

GJB2 alleles containing two cis mutations have been rarely found in non-syndromic hearing loss. Herein, we present a Korean patient with non-syndromic hearing loss caused by the R75Q cis mutation...
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The Efficacy of Connexin 43 Expression in the Myocardium as an Early Ischemic Marker in Forensic Autopsy

Ahn JW, Huh GY

The postmortem diagnosis of ischemic heart disease is sometimes difficult for forensic pathologists especially when microscopic ischemic change in the myocardium is not detected at the early stages of ischemic...
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Voltage Regulation of Connexin Channel Conductance

Oh S, Bargiello

Voltage is an important parameter that regulates the conductance of both intercellular and plasma membrane channels (undocked hemichannels) formed by the 21 members of the mammalian connexin gene family. Connexin...
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Bisphenol A and 4-tert-Octylphenol Inhibit Cx46 Hemichannel Currents

Oh S

Connexins (Cx) are membrane proteins and monomers for forming gap junction (GJ) channels. Cx46 and Cx50 are also known to function as conductive hemichannels. As part of an ongoing effort...
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Mouse Models for the Evaluation of Osteocyte Functions

Komori T

  • KMID: 2391953
  • J Bone Metab.
  • 2014 Feb;21(1):55-60.
Osteocytes establish an extensive intracellular and extracellular communication system via gap junction-coupled cell processes and canaliculi, through which cell processes pass throughout bone, and the communication system is extended to...
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Spatial relationship between expression of cytokeratin-19 and that of connexin-43 in human fetal kidney

Hieda K, Hayashi S, Kim JH, Murakami G, Cho BH, Matsubara

Connexin-43, a major gap junction protein, and cytokeratin-19, one of the intermediate filament keratins, are known to be markers of well-differentiated epithelium. In this study, we investigated the expression of...
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Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M. gerbils

Hur YN, Lee J, Sohn SC, Won CG, Lee HH, Kim DH, Choi SH, Shin KH, Chun BG

We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5...
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Apoptosis Progression in the Hair Cells in the Organ of Corti of GJB2 Conditional Knockout Mice

Zhang Y, Zhang X, Li L, Sun Y, Sun J

OBJECTIVES: Apoptosis may play an important role in the mechanism underlying the GJB2 gene conditional knockout (cCx26) mice cochlear cell death. The objective of this study was to explore the...
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Genetic Screening of GJB2 and SLC26A4 in Korean Cochlear Implantees: Experience of Soree Ear Clinic

Shin JW, Lee SC, Lee HK, Park HJ

  • KMID: 2278541
  • Clin Exp Otorhinolaryngol.
  • 2012 Apr;5(Suppl 1):S10-S13.
OBJECTIVES: Genetic hearing loss is highly heterogeneous and more than 100 genes are predicted to cause this disorder in humans. In spite of this large genetic heterogeneity, mutations in SLC26A4...
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In Silico Study of Human Gap Junction Beta-2 Protein by Homology Modeling

Shehzadi A, Masood K

  • KMID: 2166480
  • Genomics Inform.
  • 2010 Jun;8(2):70-75.
Asp66his, Asp54Lys, and Asp50Asn are mutations in connexin 26 that are observed in the clinic and give rise to autosomal dominant syndromes. They are the result of point mutations in...
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Sequence Variations and Haplotypes of the GJB2 Gene Revealed by Resequencing of 192 Chromosomes from the General Population in Korea

Kim HJ, Park CH, Kim HJ, Lee KO, Won HH, Ko MH, Chu H, Cho YS, Chung WH, Kim JW, Hong SH

OBJECTIVES: Hearing impairment (HI) is the most common sensory deficit in human. The Gap Junction Protein, Beta-2 (GJB2) gene encodes the protein connexin 26, and this gene accounts for up...
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Regulation of Gap Junctional Intercellular Communication in Human Keratinocyte Cells

Kahng HS, Kim BC, Kang SO, Hong JJ, Jun HJ, Choung YH

BACKGROUND AND OBJECTIVES: Unlike the normal skin, cholesteatomas characterized by hyperproliferative keratinocytes exhibits up-regulation of connexins (Cxs) and gap junctional intercellular communication (GJIC). Currently, there are no appropriate clinical methods...
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Hereditary Palmoplantar Keratoderma and Deafness Resulting from Genetic Mutation of Connexin 26

Lee JY, In SI, Kim HJ, Jeong SY, Choung YH, Kim YC

Gap junctions, which mediate rapid intercellular communication, consist of connexins, small transmembrane proteins that belong to a large family of proteins found throughout the species. Mutations in the GJB2 gene,...
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Ocular Manifestations and Histologic Characteristics of Keratitis-Ichthyosis-Deafness (KID) Syndrome

Jeong JH, Chun YS, Lee SH, Jeong HS, Kim JC

  • KMID: 2337672
  • J Korean Ophthalmol Soc.
  • 2008 Sep;49(9):1532-1538.
PURPOSE: Keratitis-ichthyosis-deafness (KID) syndrome is a congenital ectodermal disorder presenting the triad of vascularizing keratitis, erythrokeratoderma, and sensorineural deafness. Ocular manifestations such as hyperkeratinization of the eyelids, loss of eyelashes,...
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