- Ataxia-Telangiectasia Mutated Is Involved in Autolysosome Formation
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Hwang M, Jun DW, Song BR, Shim H, Lee CH, Kim S
- KMID: 2545713
- Biomol Ther.
- 2023 Sep;31(5):559-565.
- doi: 10.4062/biomolther.2023.003
Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been... -
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- Drug Repositioning for Treatment of Head and Neck Cancers
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Kwon M
- KMID: 2545235
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2023 Aug;66(8):505-513.
- doi: 10.3342/kjorl-hns.2023.00731
Head and neck cancer (HNC) is a complex disease that poses significant therapeutic challenges. Traditional treatment options such as surgery, radiation, and chemotherapy have limited efficacy and often result in... -
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- Infection of the Cavernous Sinus Caused by Candida auris
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Lee SH, Park SY, Lee JS, Oh J
- KMID: 2543147
- Korean J healthc assoc Infect Control Prev.
- 2023 Jun;28(1):161-171.
- doi: 10.14192/kjicp.2023.28.1.167
Candida auris (C. auris) is a pathogen that causes severe infections, particularly in healthcare settings, and is resistant to common antifungal agents, leading to a global public health threat. Infections... -
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- Epidemiology of PAH in Korea: An Analysis of the National Health Insurance Data, 2002–2018
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Jang AY, Lee HH, Lee H, Kim HC, Chung WJ
- KMID: 2542301
- Korean Circ J.
- 2023 May;53(5):313-327.
- doi: 10.4070/kcj.2022.0231
Background and Objectives: Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Recent advances in PAH-specific drugs have improved its outcomes, although the healthcare burden of novel therapeutics may... -
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- No more tears from surgical site infections in interventional pain management
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Lim S, Yoo YM, Kim KH
- KMID: 2537611
- Korean J Pain.
- 2023 Jan;36(1):11-50.
- doi: 10.3344/kjp.22397
As the field of interventional pain management (IPM) grows, the risk of surgical site infections (SSIs) is increasing. SSI is defined as an infection of the incision or organ/space that... -
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- Enhancing Anti-Cancer Therapy with Selective Autophagy Inhibitors by Targeting Protective Autophagy
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Lee MJ, Park JS, Jo SB, Joe YA
- KMID: 2537576
- Biomol Ther.
- 2023 Jan;31(1):1-15.
- doi: 10.4062/biomolther.2022.153
Autophagy is a process of eliminating damaged or unnecessary proteins and organelles, thereby maintaining intracellular homeostasis. Deregulation of autophagy is associated with several diseases including cancer. Contradictory dual roles of... -
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- A comparison of methods for the measurement of adherence to antihypertensive multidrug therapy and the clinical consequences: a retrospective cohort study using the Korean nationwide claims database
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Jung M, Choo E, Lee S
- KMID: 2544793
- Epidemiol Health.
- 2023;45(1):e2023050.
- doi: 10.4178/epih.e2023050
OBJECTIVES: In observational studies, the methods used to measure medication adherence may affect assessments of the clinical outcomes of drug therapy. This study estimated medication adherence to multidrug therapy in... -
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- Assessment of the Synergistic Effect of Seven Antimicrobial Combinations on Extensively DrugResistant Acinetobacter baumannii Strains
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Kim CM, Ko YJ, Choi JA, Kang SH, Park G, Jang SJ
- KMID: 2537136
- Ann Clin Microbiol.
- 2022 Dec;25(4):133-144.
- doi: 10.5145/ACM.2022.25.4.3
Background: To solve the difficulty in determining the appropriate treatment regimen for patients infected with extensively drug-resistant Acinetobacter baumannii (XDRAB), it is necessary to develop various strategies to increase the... -
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- Nirmatrelvir/Ritonavir Prescription Rate and Outcomes in Coronavirus Disease 2019: A Single Center Study
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Park JJ, Lee J, Seo YB, Na SH
- KMID: 2537711
- Infect Chemother.
- 2022 Dec;54(4):757-764.
- doi: 10.3947/ic.2022.0123
Background: Nirmatrelvir/ritonavir was Korea's first oral antiviral agent to treat coronavirus disease 2019 (COVID-19). We analyzed the nirmatrelvir/ritonavir prescription rate and treatment outcomes in treatment-eligible patients with COVID-19 receiving home-based... -
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- Prescription Pattern of Intravenous Fosfomycin in a Provincial Hospital in Thailand
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Thampithak A, Chaisiri K, Siangsuebchart O, Phengjaturat K, Aonjumras W, Hemapanpairoa J
- KMID: 2537706
- Infect Chemother.
- 2022 Dec;54(4):699-710.
- doi: 10.3947/ic.2022.0098
Background: In Thailand, active antibiotics against Gram-negative bacteria are limited. The re-emergence of intravenous (IV) fosfomycin is an alternative. IV fosfomycin has broadspectrum activity, relative safety, and availability. The limitations... -
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- Flexible IARPD considering the prevention of combination syndrome: a case report
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Kim Sy
- KMID: 2534506
- J Korean Acad Prosthodont.
- 2022 Oct;60(4):347-353.
- doi: 10.4047/jkap.2022.60.4.347
Traditional denture treatment is often performed in patients with the completely edentulous maxilla and the bilateral edentulous posterior mandible. However, with a long-term prognosis, a complication called ‘combination syndrome’ may... -
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- A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer
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Kim EJ, Cho YH, Kim DH, Ko DH, Do EJ, Kim SY, Kim YM, Jung JS, Kang Y, Ji W, Choi MG, Lee JC, Rho JK, Choi CM
- KMID: 2534180
- Cancer Res Treat.
- 2022 Oct;54(4):1005-1016.
- doi: 10.4143/crt.2021.986
Purpose The aim of this study is to evaluate the safety and efficacy of ex vivo activated and expanded natural killer (NK) cell therapy (SNK01) plus pembrolizumab in a randomized... -
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- A Case of Combination Therapy of IFN-β1b and Mitomycin-C on Recurred Ocular Surface Squamous Neoplasia
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Lee JK, Son BK, Jin KH
- KMID: 2533059
- J Korean Ophthalmol Soc.
- 2022 Aug;63(8):712-716.
- doi: 10.3341/jkos.2022.63.8.712
Purpose: To report a case of combination therapy with interferon β1b (IFN-β1b) and mitomycin-C (MMC) for recurrent ocular surface squamous neoplasia (OSSN). Case summary: A 72-year-old female presented with a white... -
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- Add-on Effect of Prostaglandin Analogues in Dorzolamide/Timolol Fixed Combination Treated Primary Open Angle Glaucoma Patients
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Lee JH, Jin SW
- KMID: 2533057
- J Korean Ophthalmol Soc.
- 2022 Aug;63(8):700-706.
- doi: 10.3341/jkos.2022.63.8.700
Purpose: To evaluate the additive intraocular pressure (IOP)-lowering effect of three different prostaglandin analogues in dorzolamide/timolol fixed combination (DTFC)-treated primary open angle glaucoma (POAG). Methods: In this retrospective chart review, adjunctive... -
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- Effect of the addition of thiazolidinedione to sodium-glucose cotransporter 2 inhibitor therapy on lipid levels in type 2 diabetes mellitus: a retrospective study using Korean National Health Insurance Service data
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Park T, Han K, Shin D, Park J
- KMID: 2532277
- Cardiovasc Prev Pharmacother.
- 2022 Jul;4(3):114-122.
- doi: 10.36011/cpp.2022.4.e15
Background: Dyslipidemia is common in patients with type 2 diabetes mellitus (T2D) and contributes to an increased risk of cardiovascular disease. Previous studies have shown that treatment with thiazolidinediones (TZDs)... -
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- Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer
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Yoon S, Yang H, Ryu HM, Lee E, Jo Y, Seo S, Kim D, Lee CH, Kim W, Jung KH, Park SR, Choi EK, Kim SW, Park KS, Lee DH
- KMID: 2531323
- Cancer Res Treat.
- 2022 Jul;54(3):767-781.
- doi: 10.4143/crt.2021.651
Purpose Heat shock protein-90 (HSP90) remains an important cancer target because of its involvement in multiple oncogenic protein pathways and biologic processes. Although many HSP90 inhibitors have been tested in the... -
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- Factors associated with anti-tumor necrosis factor effectiveness to prevent postoperative recurrence in Crohn’s disease
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Buisson A, Cannon L, Umanskiy K, Hurst RD, Hyman NH, Sakuraba A, Pekow J, Dalal S, Cohen RD, Pereira B, Rubin DT
- KMID: 2531984
- Intest Res.
- 2022 Jul;20(3):303-312.
- doi: 10.5217/ir.2021.00018
Background/Aims: We assessed the effectiveness of anti-TNF agents and its associated factors to prevent endoscopic and clinical postoperative recurrence (POR) in Crohn’s disease (CD). Methods: From a prospectively-maintained database, we... -
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- Tooth-implant-supported Double-crown-retained Removable Denture in a Patient with Cleft Palate: A Case Report
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Park J, Lee DH
- KMID: 2531156
- .
- 2022 Jun;26(2):103-110.
- doi: 10.32542/implantology.2022009
A 35-year-old man with left unilateral cleft palate visited our hospital for prosthetic treatment. After the existing maxillary 10-unit fixed prosthesis was removed, the severely carious teeth were extracted, and... -
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- Class duplication prescriptions in patients taking fixed-dose combination antihypertensives
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Koo H, Lee JW, Choi HE, Je NK, Jeong KH
- KMID: 2531011
- Korean J Clin Pharm.
- 2022 Jun;32(2):125-132.
- doi: 10.24304/kjcp.2022.32.2.125
Background: Fixed-dose combinations have the advantage of improving patient compliance, but may increase the risk of duplicate prescriptions. As the use of fixed-dose combination antihypertensives increases, it is necessary to... -
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- Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination
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Kim HC, Yoon DY, Lee S, Jang IJ, Hong JH, Kim J
- KMID: 2538872
- Transl Clin Pharmacol.
- 2022 Jun;30(2):112-119.
- doi: 10.12793/tcp.2022.30.e12
An extended-release (ER) fixed-dose combination (FDC) of tramadol 37.5 mg/acetaminophen 325 mg was developed due to the demand for varying dosages. This study aimed to evaluate the pharmacokinetics (PKs) for... -
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