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Gene transfer using liposome-complexed adenovirus seems to overcome limitations due to coxsackievirus and adenovirus receptor-deficiency of cancer cells, both in vitro and in vivo

Han SY, Lee YJ, Jung HI, Lee SW, Lim SJ, Hong SH, Jeong JS

Use of adenoviruses as vehicle for gene therapy requires that target cells express appropriate receptors such as coxsakievirus and adenovirus receptor (CAR). We show here that CAR-deficiency in cancer cells,...
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Effects of Chromosomal Polyploidy on Survival of Colon Cancer Cells

Park SU, Choi ES, Jang YS, Hong SH, Kim IH, Chang DK

BACKGROUND/AIMS: Tetraploid cells are frequently observed in the inflamed mucosal epithelial cells of the patients with Barrett's esophagus or chronic ulcerative colitis. Polyploidy often occurs during cell fusion, abortive cell...
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