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Phenotypic Characterization of Ligamentum Flavum Cells from Patients with Ossification of Ligamentum Flavum

Zhong ZM, Chen JT

PURPOSE: The objective of this study was to determine the phenotypic characterization of ligamentum flavum cells from patients with ossification of the ligamentum flavum (OLF). MATERIALS AND METHODS: Ligamentum flavum...
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Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms

Cho H, Park SH, Lee S, Kang M, Hasty KA, Kim SJ

Larger animal models, such as porcine, have been validated as appropriate models of the human disc with respect to biomechanics and biochemistry. They are advantageous for research as the models...
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Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits

Chen B, Qin J, Wang H, Magdalou J, Chen L

The study investigated the effects of adenovirus-mediated gene transfection of basic fibroblast growth factor (bFGF), bFGF combined with interleukin-1 receptor antagonist protein (IL-Ra) and/or insulin-like growth factor-1 (IGF-1) both in...
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Overexpression of SOX9 in mouse embryonic stem cells directs the immediate chondrogenic commitment

Kim JH, Do HJ, Yang HM, Oh JH, Choi SJ, Kim DK, Cha KY, Chung HM

  • KMID: 1093460
  • Exp Mol Med.
  • 2005 Aug;37(4):261-268.
Mouse embryonic stem (mES) cells are capable of undergoing chondrogenesis in vitro. To enhance this process, the human SOX9 (hSOX9) cDNA was delivered into mES cells and the clones overexpressing...
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Biologic Response of Degenerative Living Human Nucleus Pulposus Cells to Treatment with Cytokines

Kim SH, Kuh SU, Kim KN, Park JY, Cho KH, Chin DK, Kim KS, Cho YE

PURPOSE: To investigate the molecular responses of various genes and proteins related to disc degeneration upon treatment with cytokines that affect disc-cell proliferation and phenotype in living human intervertebral discs...
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