- Microbiome and metabolomics in alcoholic liver disease
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Ganesan R, Suk KT
- KMID: 2531381
- Clin Mol Hepatol.
- 2022 Jul;28(3):580-582.
- doi: 10.3350/cmh.2022.0171
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- Association of nonalcoholic fatty liver disease with incident dementia later in life among elderly adults
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Ye BS
- KMID: 2531372
- Clin Mol Hepatol.
- 2022 Jul;28(3):481-482.
- doi: 10.3350/cmh.2022.0097
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- Clinical significance of the discrepancy between radiological findings and biochemical responses in atezolizumab plus bevacizumab for hepatocellular carcinoma
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Iwamoto H, Shimose S, Niizeki T, Koga H, Torimura T, The Kurume Liver Cancer Study Group of Japan
- KMID: 2531380
- Clin Mol Hepatol.
- 2022 Jul;28(3):575-579.
- doi: 10.3350/cmh.2022.0047
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- Does nonalcoholic fatty liver disease predispose patients to carotid arteriosclerosis and ischemic stroke?
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Jin Q, Yang RX, Fan JG
- KMID: 2531370
- Clin Mol Hepatol.
- 2022 Jul;28(3):473-477.
- doi: 10.3350/cmh.2022.0155
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- A crystal ball to forecast treatment responsiveness in nonalcoholic fatty liver disease
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Hwang S, Kim W
- KMID: 2531371
- Clin Mol Hepatol.
- 2022 Jul;28(3):478-480.
- doi: 10.3350/cmh.2022.0143
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- Statin and aspirin for chemoprevention of hepatocellular carcinoma: Time to use or wait further?
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Goh MJ, Sinn DH
- KMID: 2531366
- Clin Mol Hepatol.
- 2022 Jul;28(3):380-395.
- doi: 10.3350/cmh.2021.0366
Preclinical studies highlighted potential therapeutic applications of aspirin and statins as anticancer agents based on their pleiotropic effects. Epidemiologic studies suggested the role of aspirin and statins in the chemoprevention... -
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- Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma
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Sung PS
- KMID: 2531363
- Clin Mol Hepatol.
- 2022 Jul;28(3):333-350.
- doi: 10.3350/cmh.2021.0308
The tumor microenvironment generally shows a substantial immunosuppressive activity in hepatocellular carcinoma (HCC), accounting for the suboptimal efficacy of immune-based treatments for this difficult-to-treat cancer. The crosstalk between tumor cells... -
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- Intrahepatic cholangiocarcinoma: Tumour heterogeneity and its clinical relevance
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Komuta M
- KMID: 2531367
- Clin Mol Hepatol.
- 2022 Jul;28(3):396-407.
- doi: 10.3350/cmh.2021.0287
Treatment of intrahepatic cholangiocarcinoma (iCCA) is currently at a significant turning point due to the identification of isocitrate dehydrogenase (IDH) mutations and fibroblast growth factor receptor (FGFR) fusions that can... -
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- Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases
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Lee HA, Chang Y, Sung PS, Yoon EL, Lee HW, Yoo JJ, Lee YS, An J, Song DS, Cho YY, Kim SU, Kim YJ
- KMID: 2531369
- Clin Mol Hepatol.
- 2022 Jul;28(3):425-472.
- doi: 10.3350/cmh.2022.0186
The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment... -
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- Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals
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Tang ASP, Chan KE, Quek J, Xiao J, Tay P, Teng M, Lee KS, Lin SY, Myint MZ, Tan B, Sharma VK, Tan DJH, Lim WH, Kaewdech A, Huang D, Chew NW, Siddiqui MS, Sanyal AJ, Muthiah M, Ng CH
- KMID: 2531373
- Clin Mol Hepatol.
- 2022 Jul;28(3):483-496.
- doi: 10.3350/cmh.2021.0406
Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with the development of cardiovascular disease. While existing studies have examined cardiac remodeling in NAFLD, there has been less emphasis on the... -
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- Gut-derived lipopolysaccharide promotes alcoholic hepatosteatosis and subsequent hepatocellular carcinoma by stimulating neutrophil extracellular traps through toll-like receptor 4
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Liu Y, Zhang X, Chen S, Wang J, Yu S, Li Y, Xu M, Aboubacar H, Li J, Shan T, Wang J, Cao G
- KMID: 2531376
- Clin Mol Hepatol.
- 2022 Jul;28(3):522-539.
- doi: 10.3350/cmh.2022.0039
Background/Aims: Binge drinking leads to many disorders, including alcoholic hepatosteatosis, which is characterized by intrahepatic neutrophil infiltration and increases the risk of hepatocellular carcinoma (HCC). Molecular mechanisms may involve the... -
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- The effect of diabetes and prediabetes on the prevalence, complications and mortality in nonalcoholic fatty liver disease
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Ng CH, Chan KE, Chin YH, Zeng RW, Tsai PC, Lim WH, Tan DJH, Khoo CM, Goh LH, Ling ZJ, Kulkarni A, Mak LYL, Huang DQ, Chan M, Chew NW, Siddiqui MS, Sanyal AJ, Muthiah M
- KMID: 2531379
- Clin Mol Hepatol.
- 2022 Jul;28(3):565-574.
- doi: 10.3350/cmh.2022.0096
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely associated with diabetes. The cumulative impact of both diseases synergistically increases risk of adverse events. However, present population analysis is predominantly conducted... -
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- The best predictive model for hepatocellular carcinoma in patients with chronic hepatitis B infection
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Yu JH, Cho SG, Jin YJ, Lee JW
- KMID: 2531364
- Clin Mol Hepatol.
- 2022 Jul;28(3):351-361.
- doi: 10.3350/cmh.2021.0281
Chronic hepatitis B (CHB) seriously threatens human health. About 820,000 deaths annually are due to related complications such as hepatitis B and hepatocellular carcinoma (HCC). Recently, the use of oral... -
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- Association of non-alcoholic fatty liver disease with incident dementia later in life among elder adults
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Jeong S, Oh YH, Choi S, Chang J, Kim SM, Son JS, Lee G, Ahn JC, Lee DH, Koo BK, Kim W, Park SM
- KMID: 2531375
- Clin Mol Hepatol.
- 2022 Jul;28(3):510-521.
- doi: 10.3350/cmh.2021.0332
Background/Aims: Accumulating evidence suggests a link between non-alcoholic fatty liver disease (NAFLD) and brain health. However, population-based evidence on the association between NAFLD and dementia remains unclear. This study was... -
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- Imaging diagnosis of hepatocellular carcinoma: Future directions with special emphasis on hepatobiliary magnetic resonance imaging and contrast-enhanced ultrasound
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Park J, Lee JM, Kim TH, Yoon JH
- KMID: 2531365
- Clin Mol Hepatol.
- 2022 Jul;28(3):362-379.
- doi: 10.3350/cmh.2021.0361
Hepatocellular carcinoma (HCC) is a unique cancer entity that can be noninvasively diagnosed using imaging modalities without pathologic confirmation. In 2018, several major guidelines for HCC were updated to include... -
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- RNA interference as a novel treatment strategy for chronic hepatitis B infection
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Hui RWH, Mak LY, Seto WK, Yuen MF
- KMID: 2531368
- Clin Mol Hepatol.
- 2022 Jul;28(3):408-424.
- doi: 10.3350/cmh.2022.0012
Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality. Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) seroclearance, is associated with improved... -
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- Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients
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Cheung KS, Lam LK, Hui RWH, Mao X, Zhang RR, Chan KH, Hung IF, Seto WK, Yuen MF
- KMID: 2531378
- Clin Mol Hepatol.
- 2022 Jul;28(3):553-564.
- doi: 10.3350/cmh.2022.0082
Background/Aims: Studies of hepatic steatosis (HS) effect on COVID-19 vaccine immunogenicity are lacking. We aimed to compare immunogenicity of BNT162b2 and CoronaVac among moderate/severe HS and control subjects. Methods: Two hundred... -
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- Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial
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Oh JH, Jun DW, Kim HY, Lee SM, Yoon EL, Hwang J, Park JH, Lee H, Kim W, Kim H
- KMID: 2531374
- Clin Mol Hepatol.
- 2022 Jul;28(3):497-509.
- doi: 10.3350/cmh.2022.0019
Background/Aims: We aimed to define an optimal target population and drug-specific biomarkers that may predict dipeptidyl peptidase (DPP)-4 inhibitor responses in non-alcoholic fatty liver disease (NAFLD). Methods: An exploration study (study... -
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- Reappraisal of sepsis-3 and CLIF-SOFA as predictors of mortality in patients with cirrhosis and infection presenting to the emergency department: A multicenter study
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Kim JH, Jun BG, Lee M, Lee HA, Kim TS, Heo JW, Moon DH, Kang SH, Suk KT, Kim MY, Kim YD, Cheon GJ, Baik SK, Kim DJ, Choi DH
- KMID: 2531377
- Clin Mol Hepatol.
- 2022 Jul;28(3):540-552.
- doi: 10.3350/cmh.2021.0169
Background/Aims: Sepsis-3 criteria and quick Sequential Organ Failure Assessment (qSOFA) have been advocated to be used in defining sepsis in the general population. We aimed to compare the Sepsis-3 criteria... -
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