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Acute on chronic liver failure in cirrhosis

Tonon M, Piano S

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KASL clinical practice guidelines for management of chronic hepatitis B

The Korean Association for the Study of the Liver (KASL)

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Dyslipidemia in chronic hepatitis B patients on tenofovir alafenamide: Facts and puzzles

Lin HY, Tseng TC

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Surgical resection versus ablation for early hepatocellular carcinoma: The debate is still open

Kim BH

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Reply: Letter: cervicocerebral atherosclerosis and its hepatic and coronary risk factors in patients with liver cirrhosis

An J, Shim JH

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Leaky gut-derived tumor necrosis factor-α causes sarcopenia in patients with liver cirrhosis

Kawaguchi T, Torimura T

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Effects of interleukin-17 inhibitors on hepatic fibrosis index in patients with psoriasis and metabolic dysfunction-associated fatty liver disease: Directed acyclic graphs

Takamura S, Teraki Y, Katayama E, Kawaguchi T, Kawaguchi M, Nakano D, Tsutsumi T, Nagoshi S, Nakama T, Torimura T

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Letter: cervicocerebral atherosclerosis and its hepatic and coronary risk factors in patients with liver cirrhosis

Huang YC, Chen CW, Wei JCC

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Prevalence trends of non-alcoholic fatty liver disease among young men in Korea: A Korean military population-based cross-sectional study

Lee J, Kim T, Yang H, Bae SH

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) has become a major concern in Korea since its emergence as a dominant cause of chronic liver disease. However, no study has explored its...
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Approaches to quantifying hepatitis B virus covalently closed circular DNA

Zhang H, Tu T

Chronic hepatitis B is a major cause of liver disease worldwide and is currently incurable. Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the...
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Protective association of Klotho rs495392 gene polymorphism against hepatic steatosis in non-alcoholic fatty liver disease patients

Liu WY, Zhang X, Li G, Tang LJ, Zhu PW, Rios RS, Zheng KI, Ma HL, Wang XD, Pan Q, de Knegt RJ, Valenti L, Ghanbari M, Zheng MH

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic variation acts as important modifiers. Klotho, an enzyme encoded by the klotho (KL)...
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The role of transjugular intrahepatic portosystemic shunt in patients with portal hypertension: Advantages and pitfalls

Lee HL, Lee SW

Transjugular intrahepatic portosystemic shunt (TIPS) is an effective interventional procedure to relieve portal hypertension, which is a main mechanism for the development of complications of liver cirrhosis (LC), such as...
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Galectin-3 inhibits cardiac contractility via a tumor necrosis factor alpha-dependent mechanism in cirrhotic rats

Yoon KT, Liu H, Zhang J, Han S, Lee SS

Background/Aims: Galectin-3 plays a key pathogenic role in cardiac hypertrophy and heart failure. The present study aimed to investigate the effects of galectin-3 on cardiomyopathy – related factors and cardiac...
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MAFLD enhances clinical practice for liver disease in the Asia-Pacific region

Kawaguchi T, Tsutsumi T, Nakano D, Eslam M, George J, Torimura T

Fatty liver is now a major cause of liver disease in the Asia-Pacific region. Liver diseases in this region have distinctive characteristics. First, fatty liver is frequently observed in lean/normal-weight...
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Association between serum tumor necrosis factor-α and sarcopenia in liver cirrhosis

Han JW, Kim DI, Nam HC, Chang UI, Yang JM, Song DS

Background/Aims: Sarcopenia is an independent prognostic factor of liver cirrhosis (LC). However, the association between LC-related systemic inflammation and sarcopenia is unclear. Methods: Sprague-Dawley rats were treated with thioacetamide (TAA) or...
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Cost-effectiveness of chronic hepatitis C screening and treatment

Lee HW, Lee H, Kim BK, Chang Y, Jang JY, Kim DY

Hepatitis C virus (HCV) infection is the second most common cause of chronic liver disease in South Korea, with a prevalence ranging from 0.6% to 0.8%, and HCV infection incidence...
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Tenofovir alafenamide treatment may not worsen the lipid profile of chronic hepatitis B patients: A propensity score-matched analysis

Jeong J, Shin JW, Jung SW, Park EJ, Park NH

Background/Aims: Tenofovir alafenamide (TAF) has shown less favorable effect on lipids compared to tenofovir disoproxil fumarate (TDF) in clinical trials. However, data regarding these outcomes in patients with chronic hepatitis...
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Cause of death and cause-specific mortality for primary liver cancer in South Korea: A nationwide population-based study in hepatitis B virus-endemic area

Kim BH, Lee D, Jung KW, Won YJ, Cho H

Background/Aims: Primary liver cancer is one of the leading causes of cancer mortality worldwide. However, the causes of death have not been studied in detail in patients with liver cancer. Methods:...
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Surgery versus radiofrequency ablation in patients with Child- Pugh class-A/single small (≤3 cm) hepatocellular carcinoma

Lee J, Jin YJ, Shin SK, Kwon JH, Kim SG, Suh YJ, Jeong Y, Yu JH, Lee JW, Kwon OS, Nahm SW, Kim YS

Background/Aims: We compared the post-treatment overall survival (OS) and recurrence-free survival (RFS) between patients with Child-Turcotte-Pugh (CTP) class-A and single small (≤3 cm) hepatocellular carcinoma (HCC) treated by surgical resection...
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