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Adverse Factors and the Role of Cisplatin and Vinca Alkaloids for Hearing Impairment in Childhood Cancer Patients and Survivors

Hur MW, Hahn SM, Moon IS, Lim JY, Lee SM, Lyu CJ, Han JW

BACKGROUND: Although combined chemotherapy has increased survival rates among children with cancer, such treatments can induce sensorineural hearing loss. Therefore, we aimed to identify risk factors for hearing impairments in...
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A Case of Pediatric Precursor B-cell Acute Lymphoblastic Leukemia Associated with Translocations (14;18)(q32;q21) and (8;9)(q24;p13)

Kim HJ, Kim H, Koh KN, Im HJ, Seo JJ, Seo EJ, Park CJ

Precursor B-cell acute lymphoblastic leukemia (ALL), which is the most common subtype of pediatric acute leukemia, generally has a good prognosis. However, the prognosis also depends on the genetic abnormalities...
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PHACE Syndrome with Large Facial Segmental Hemangioma and Cerebellar Hypoplasia

Lee YJ, Yeon GM, Kong SG

Infantile hemangiomas are the most common benign tumors in infants. Facial segmental hemangiomas are often accompanied by other anomalies, and pre-treatment evaluation is needed. PHACE syndrome is associated with Posterior...
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Clinical Course of Childhood Immune Thrombocytopenic Purpura and Analysis Predicting Factor of Prognosis

Lee T, Choi J, Lim YJ

BACKGROUND: Immune thrombocytopenic purpura (ITP) is an acquired bleeding disorder in which the immune system destroys platelets. There were many studies which predicted the factors associated with the prognosis of...
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2 Cases of Beta-thalassemia Minor in Korea

Kim EJ, Jeung SW, Yoon HS

In Korea, recent epidemiologic studies show that the incidence of β-thalassemia is increasing as the influx of South-East Asian population increases and molecular technologies develop. However, many patients are still...
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A Case of Recurrent Steroid-dependent Kikuchi-Fujimoto Disease Successfully Treated with Hydroxychloroquine

Jang KM, Lee JM

Kikuchi-Fujimoto disease (KFD) is known as a self-limiting disease. The most common symptoms include fever, cervical lymphadenopathy, and pain, but nonspecific symptoms such as joint pain, nausea, chills, diaphoresis, and...
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Clinical Features and Treatment Outcome of Soft Tissue Clear Cell Sarcoma

An HY, Baek SM, Kim BK, Choi JY, Hong KT, Hong CR, Choi TH, Kim HS, Kim TM, Kang HJ, Shin HY

BACKGROUND: Soft tissue clear cell sarcoma is a rare tumor which originates from neural crest cells. Due to its rarity and lack of established treatment, the prognosis of clear cell...
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Clinical Characteristics of Severe Neutropenia in Children

Cheon E, Hwang I, Jung HJ, Park JE

BACKGROUND: Severe neutropenia is defined as an absolute neutrophil count (ANC) less than 0.5×109/L, which is known to increase the risk of serious bacterial infections. The aim of this study...
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Characteristics of Peripheral Polyneuropathy after Chemotherapy in Pediatric Acute Lymphoblastic Leukemia

Min YS, Kang MG, Kim JY

BACKGROUND: Vincristine is an antimitotic agent used for treatment of leukemia, lymphomas, and cancers. Its main side effect is a dose-related, length-dependent axonal neuropathy. METHODS: We performed electrodiagnostic examinations in 18...
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Pediatric Ewing's Sarcoma/Primitive Neuroectodermal Tumor (ES/PNET) Developed in the Small Intestine: A Case Report

Kim YS, Moon HM, Lee KS, Park YS, Kim HY, Kim JY, Cho JM, Choi HS

Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) are a group of malignant tumors with varying degrees of neuroectodermal differentiation. Although it may develop in any organs, ES/PNET originating from small intestine is...
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Isolated Pulmonary Langerhans Cell Histiocytosis in an Infant Diagnosed by CD1a Immunostaining of Bronchoalveolar Lavage Cells: A Case Report and Literature Review

Kim MJ, Yoo JH, Cho YW, Yoo JW, Kang SH, Kim H, Koh KN, Im HJ, Seo JJ

Isolated pulmonary Langerhans cell histiocytosis (LCH) is a very rare disease in childhood. We report a case of a 5-month-old girl with isolated pulmonary LCH, who was transferred due to...
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Reversible Metronidazole-induced Encephalopathy in a Patient with Acute Lymphoblastic Leukemia during Chemotherapy

Bae H, Lee SM, Kim JY

We describe our experience regarding metronidazole-induced encephalopathy in a patient with acute lymphoblastic leukemia during chemotherapy. A 17-year-old girl was admitted to our institution with complaints of abdominal pain and...
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Differences in Mobilization Efficiency between Small Children and Adults with Healthy Marrows

Shin EK, Kim DY, Rah WJ, Koh H, Suh JY, Chang M, Nam E, Lee YH

BACKGROUND: We compared the yields of mobilized PBSCs from single day of normal volume leukapheresis (NVL) in children and adults, and factors affecting the yields, to understand differences in mobilization...
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A Multicenter Study on Korean von Willebrand Disease Realities

Seol JH, Kim HJ, Kim SK, Yoo KY, Shim YJ, Baek HJ, Park YS, Choi EJ, Park SK

BACKGROUND: von Willebrand disease (VWD) is the most common inherited bleeding disorder with a prevalence of up to 1%. However in Korea, only 126 VWD patients were registered in Korea...
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A Multicenter Retrospective Analysis on the Treatment Pattern and Outcome in Relapsed/Refractory Childhood Acute Lymphoblastic Leukemia

Yoo KH, Chung NG, Cho B, Kang HJ, Shin HY, Im HJ, Seo JJ, Lim YT, Lyu CJ, Kim SK, Jeon IS, Kook H, Koo HH

BACKGROUND: Although the overall survival of childhood acute lymphoblastic leukemia (ALL) approaches 85-90%, the prognosis of relapsed or refractory (R/R) ALL is grave. This study aimed to identify the treatment...
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