- Troglitazone Increases the Susceptibility to TRAIL-Induced Apoptosis in Thyroid Cancer Cell Lines
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Park JW, Clark OH
- KMID: 2376132
- Korean J Endocr Surg.
- 2003 Oct;3(2):113-120.
- doi: 10.16956/kjes.2003.3.2.113
PURPOSE: Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis in many human cancer cells but not in normal cells. Thyroid cancer cells, however, appear to be relatively resistant to... -
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- New Promising Therapeutic Modalities for Thyroid Cancers: Histone Deacetylase Inhibitor, PPAR-gamma Agonist, and Retinoic Acid
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Chung WY, Clark OH
- KMID: 2375954
- Korean J Endocr Surg.
- 2005 Dec;5(2):69-74.
- doi: 10.16956/kjes.2005.5.2.69
Most patients with thyroid cancer have well differentiated tumors that usually respond to conventional therapy including total or near total thyroidectomy, radioiodine ablation and TSH suppression. About 10% of patients,... -
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- Redifferentiation Effects of Troglitazone in Human Thyroid Cancer Cell Lines
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Park JC, Ryu DH, Park JW, Clark OH
- KMID: 2096184
- J Korean Surg Soc.
- 2004 Aug;67(2):93-99.
PURPOSE: Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-gamma (PPARgamma), which is a ligand-activated transcription factor that regulates cell differentiation and growth. Antiproliferative effects of troglitazone have been... -
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- Regulation of Sodium-iodine Symporter Expression by Retinoic Acid in Thyroid Cancer Cell Lines
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Chung KW, Song MS, Park JW, Clark OH, Noh DY, Oh SK, Choe KJ, Youn YK
- KMID: 2376119
- Korean J Endocr Surg.
- 2004 Jun;4(1):1-9.
- doi: 10.16956/kjes.2004.4.1.1
PURPOSE: Response to radioiodine therapy for thyroid cancer is related to the loss of sodium-iodine symporter protein caused by dedifferentiation of thyroid cancer cells. So we aimed to study mRNA... -
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- Sonic Hedgehog Protein Expression in Various Thyroid Tissues and Its Clinical Implication
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Ryu KS, Lee OJ, Kim WJ, Park SS, Kim DJ, Park JW, Choi JW, Jang LC, Clark OH
- KMID: 2375383
- Korean J Endocr Surg.
- 2011 Dec;11(4):234-241.
- doi: 10.0000/kjes.2011.11.4.234
PURPOSE: The Hedgehog (Hh) signaling pathway is important in embryonic development including cell differentiation and proliferation. Recently, activation of this pathway has been implicated in several forms of solid cancers.... -
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- Cyclopamine Inhibits Cancer Cell Proliferation in Thyroid Cancer Cell Lines
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Park SS, Park JW, Choi JW, Jang LC, Woo SI, Choi YJ, Clark OH
- KMID: 2375887
- Korean J Endocr Surg.
- 2007 Jun;7(2):69-74.
- doi: 10.16956/kjes.2007.7.2.69
PURPOSE: The Hedgehog (HH) signaling pathway is important in development. Recently,ectopic activation of this pathway has been implicated in several forms of solid cancer including basal cell carcinoma, pancreatic cancer,... -
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- The Antiproliferative and Redifferentiative Effects of Na-4-Phenylbutyrate in Human Thyroid Cancer Cell Lines
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Choi YJ, Park JW, Jang LC, Choi JW, Clark OH
- KMID: 1476278
- J Korean Surg Soc.
- 2008 Sep;75(3):162-170.
PURPOSE: Sodium-4-phenylbutyrate (Na-4-PB) is an analogue of phenylacetate, which is a well-known redifferentiating agent. In vitro and in vivo studies on this agent have been done and the clinical relevance... -
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