- The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells
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Han JY, Chung YJ, Park SW, Kim JS, Rhyu MG, Kim HK, Lee KS
- KMID: 759083
- Korean J Intern Med.
- 1999 Jan;14(1):42-52.
OBJECTIVES: Given the roles of bcl-2, bax and p53 in apoptosis, we investigated the effect of their expression on the response to cisplatin in order to understand the... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- Antitumor activity of five new platinum complexes having a glycolate leaving ligand
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Hong WS, Min YI, Kim HT, Cho YB, Kim KH, Kim DK
- KMID: 644887
- J Korean Med Sci.
- 1995 Aug;10(4):269-274.
- doi: 10.3346/jkms.1995.10.4.269
In an attempt to develop a new anticancer platinum complex with greater or equivalent antitumor activity but reduced side effects compared with cisplatin (CDDP), a series of new platinum complexes... -
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- IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species
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Paek AR, Kim SH, Kim SS, Kim KT, You HJ
- KMID: 964664
- Exp Mol Med.
- 2010 Oct;42(10):696-702.
- doi: 10.3858/emm.2010.42.10.068
Expression of zinc-finger protein 143 (ZNF143), a human homolog of the Xenopus transcriptional activator protein Staf, is induced by various DNA-damaging agents including etoposide, doxorubicin, and gamma-irradiation. ZNF143 binds to... -
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- Suppression of Aurora-A oncogenic potential by c-Myc downregulation
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Yang S, He S, Zhou X, Liu M, Zhu H, Wang Y, Zhang W, Yan S, Quan L, Bai J, Xu N
- KMID: 994399
- Exp Mol Med.
- 2010 Nov;42(11):759-767.
- doi: 10.3858/emm.2010.42.11.077
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how... -
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