- Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
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Xu Z, Hu J, Cao H, Pilo MG, Cigliano A, Shao Z, Xu M, Ribback S, Dombrowski F, Calvisi DF, Chen X
- KMID: 2438347
- Exp Mol Med.
- 2018 Jan;50(1):e417.
- doi: 10.1038/emm.2017.158
Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase... -
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