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Two Cases of Idiopathic Progressive Sensorineural Hearing Loss with Positional Nystagmus in Postpartum Period: Possible Spontaneous Perilymph Fistula?

Park M, Kim HJ, Chung WH

Perilymph fistula (PLF) is defined as an abnormal communication between the middle ear cavity and perilymphatic space of the inner ear. Most cases of PLF are responsible for pressure change...
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Significance of Pseudo-Conductive Hearing Loss and Positional Nystagmus for Perilymphatic Fistula: Are They Related to Third-Window Effects?

Kim JS, Son SE, Kim MB, Cho YS, Chung WH

Objectives. Patients’ clinical presentation is critical for identifying suspected perilymphatic fistula (PLF). The involvement of third-window lesions in the pathomechanism of PLF has been hypothesized. This study investigated the clinical...
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Two Cases of Recurred Vertigo Following Perilymphatic Oval Window Fistula Repair

Kim HJ, Chung WH

The traumatic perilymphatic fistula (PLF) can cause hearing loss and disabling dizziness. These symptoms can be recovered spontaneously or by surgical repair. However, even after surgical PLF repair, patients may suffer...
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Drug hypersensitivity reactions in Asia: regional issues and challenges

Thong BY, Lucas M, Kang HR, Chang YS, Li PH, Tang MM, Yun J, Fok JS, Kim BK, Nagao M, Rengganis , Tsai YG, Chung WH, Yamaguchi , Rerkpattanapipat T, Kamchaisatian W, Leung TF, Yoon HJ, Zhang L, Latiff AH, Fujisawa T, Thien F, Castells M, Demoly P, Wang JY, Pawankar R

There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug...
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A Case of Lipoma in the Middle Ear

Park SI, Park MH, Ahn J, Chung WH

Lipoma is a common benign tumor found at various sites in the body, but it is rarely encountered in the middle ear. We report a case of a 5-month-old girl...
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Case Series Outcomes of Cochlear Implantation in Children with Noonan Syndrome

Chang YS, Ahn J, Hong SH, Kim EY, Chung WH, Cho YS, Moon IJ

BACKGROUND AND OBJECTIVES: Hearing loss is a common complication associated with Noonan syndrome (NS), and the level of hearing loss for NS patients with sensorineural loss ranged from normal to...
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Two Cases of Localized Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Manifested with Intractable Otitis Media

Lee E, Chung WH

Localized form of myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis (MPO-AAV) in the ear is a rare disease. It manifests as a sudden otalgia with hearing loss accompanied by dizziness and facial nerve...
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Novel Patched 1 Mutations in Patients with Gorlin-Goltz Syndrome Strategic Treated by Smoothened Inhibitor

Hsu SW, Lin CY, Wang CW, Chung WH, Yang CH, Chang YY

We studied a family with Gorlin-Goltz syndrome. The novel mutations of our cases were located on the 21st exon of the PTCH1 gene (c.3450C>G). The father, who received a strategic...
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Comparison of Endoscopic Tympanoplasty to Microscopic Tympanoplasty

Choi N, Noh Y, Park W, Lee JJ, Yook S, Choi JE, Chung WH, Cho YS, Hong SH, Moon IJ

OBJECTIVES: This study aimed to compare the outcome of endoscopic and microscopic tympanoplasty. METHODS: This was a retrospective comparative study of 73 patients (35 males and 38 females) who underwent type...
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Multicenter Randomized Study on the Efficacy of Isosorbide in Patients with Mèniére's Disease

Park HW, Chung WH, Kim SH, Kim KS, Chung JW, Chae SW, Koo JW, Kim BG, Goh EK, Han GC

OBJECTIVES: Mèniére's disease is one of the most common causes of episodic vestibular syndrome that shows symptom complexes of recurrent vertigo, hearing loss, tinnitus and ear fullness. Isosorbide (Isobide) is...
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Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats

Chung HJ, Chung WH, Lee JH, Chung DJ, Yang WJ, Lee AJ, Choi CB, Chang HS, Kim DH, Suh HJ, Lee DH, Hwang SH, Do SH, Kim HY

We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor...
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Diagnostic Criteria for Meniere's Disease

Lopez-Escamez JA, Careyb J, Chung WH, Goebeld JA, Magnusson , Mandala M, Newman-Tokerg DE, Strupp M, Suzuki M, Trabalzini F, Bisdorff A

This paper presents diagnostic criteria for Meniere's disease jointly formulated by the Classification Committee of the Barany Society, The Japan Society for Equilibrium Research, the European Academy of Otology and...
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Effect of Next-Generation Exome Sequencing Depth for Discovery of Diagnostic Variants

Kim K, Seong MW, Chung WH, Park SS, Leem S, Park W, Kim J, Lee K, Park RW, Kim N

Sequencing depth, which is directly related to the cost and time required for the generation, processing, and maintenance of next-generation sequencing data, is an important factor in the practical utilization...
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Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms

Dao RL, Su SC, Chung WH

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the...
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Two Cases of Barotraumatic Perilymph Fistula Mimicking Atypical Benign Paroxysmal Positional Vertigo with Sudden Hearing Loss

Lee JJ, Ryu G, Moon IJ, Chung WH

Barotraumatic perilymph fistula is difficult to diagnose and needs diagnosis of suspicion. Symptoms like hearing loss, tinnitus, ear fullness and positional dizziness can develop following barotrauma such as valsalva, nose...
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Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children

Ryu NG, Moon IJ, Chang YS, Kim BK, Chung WH, Cho YS, Hong SH

OBJECTIVES: Neuroblastoma (NBL) predominantly affects children under 5 years of age. Through multimodal therapy, including chemotherapy, radiotherapy, surgery, and peripheral blood stem cell transplantation, the survival rate in patients with...
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Quantitative measurement of influenza virus replication using consecutive bronchoalveolar lavage in the lower respiratory tract of a ferret model

Lee DH, Kim JI, Lee JW, Chung WH, Park JK, Lee YN, Han JS, Kim HY, Lee SW, Song CS

The ferret is an established animal model of influenza virus infection. Although viral replication in the upper respiratory tract is usually measured with consecutively collected nasal washes, daily evaluation of...
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Persistent Direction-Fixed Nystagmus Following Canalith Repositioning Maneuver for Horizontal Canal BPPV: A Case of Canalith Jam

Chang YS, Choi J, Chung WH

  • KMID: 2278389
  • Clin Exp Otorhinolaryngol.
  • 2014 Jun;7(2):138-141.
The authors report a 64-year-old man who developed persistent direction fixed nystagmus after a canalith repositioning maneuver for horizontal canal benign paroxysmal positional vertigo (HC-BPPV). The patient was initially diagnosed...
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Residual Vestibulo-Ocular Reflex Result in Better Functional Outcomes in Bilateral Vestibulopathy

Choi JE, Ryu G, Cho YS, Chung WH

  • KMID: 1736996
  • Res Vestib Sci.
  • 2014 Dec;13(4):89-95.
BACKGROUND AND OBJECTIVES: The patients with bilateral vestibulopathy (BV) suffer from unsteadiness and oscillopsia, and despite of appropriate rehabilitation, permanent disability is inevitable. However, the level of functional outcomes could...
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Multicenter Study on the Clinician's Diagnostic and Therapeutic Approaches for Benign Paroxysmal Positional Vertigo in Korea

Jeon EJ, Chung WH, Choi JH, Nam EC, Park HJ, Lee JD, Lee WS, Kim KS, Goh EK, Koo JW, Kim MB, Kim MB, Kim SH, Kim YJ, Kim CH, Nam SI, Mun SK, Park GY, Park SY, Park SN, Bae CH, Boo SH, Suh MW, Seo JH, Son EJ, Song JJ, Song JJ, Shin JW, Shim DB, Ahn SK, Youm HY, Yoo SY, Lee DH, Lee SH, Lee CH, Lee HS, Lee HH, Lee HJ, Choung YH, Choi SH, Choi JS, Hong SM, Hong SK

  • KMID: 2316798
  • Res Vestib Sci.
  • 2013 Sep;12(3):79-92.
BACKGROUND AND OBJECTIVES: It is necessary to establish the most efficient diagnostic and therapeutic method for benign paroxysmal positional vertigo (BPPV), which is appropriate for Korean healthcare system. We aimed...
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