- Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma
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Zhang B, Han S, Feng B, Chu X, Chen L, Wang R
- KMID: 2375023
- Exp Mol Med.
- 2017 Feb;49(2):e293.
- doi: 10.1038/emm.2016.177
Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations... -
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- Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa
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Su S, Zhao Q, Dan L, Lin Y, Li X, Zhang Y, Yang C, Dong Y, Li X, Regazzi R, Sun C, Chu X, Lu H
- KMID: 2537291
- Endocrinol Metab.
- 2022 Dec;37(6):901-917.
- doi: 10.3803/EnM.2022.1565
Background: Chronic exposure to elevated levels of saturated fatty acids results in pancreatic β-cell senescence. However, targets and effective agents for preventing stearic acid-induced β-cell senescence are still lacking. Although... -
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- TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD
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Sun B, Ding X, Tan J, Zhang J, Chu X, Zhang S, Liu S, Zhao Z, Xuan S, Xin Y, Zhuang L
- KMID: 2560090
- Clin Mol Hepatol.
- 2024 Oct;30(4):863-882.
- doi: 10.3350/cmh.2024.0268
Backgrounds/Aims: Transmembrane 6 superfamily member 2 (TM6SF2) E167K variant is closely associated with the occurrence and development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the role and mechanism of... -
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