- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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- Rapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
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Park CE, Ko SM, Kim JM, Yoon MY, Kim JY, Kang IS, Kim SS, Ha JH
- KMID: 754991
- Exp Mol Med.
- 1998 Jun;30(2):73-79.
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, alpha and beta, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-alpha is highly expressed in lipogenic tissues whereas... -
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- Interleukin-1 beta Induces MUC2 Gene Expression and Mucin Secretion via Activation of PKC-MEK/ERK,and PI3K in Human Airway Epithelial Cells
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Kim YD, Jeon JY, Woo HJ, Lee JC, Chung JH, Song SY, Yoon SK, Baek SH
- KMID: 648785
- J Korean Med Sci.
- 2002 Dec;17(6):765-771.
- doi: 10.3346/jkms.2002.17.6.765
Interleukin 1 beta (IL-1 beta), a proinflammatory cytokine, is related with inflammatory diseases and it up-regulates MUC2 gene expression and mucin secretion. This study was designed to investigate the... -
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- Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3beta signaling pathway
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Jun HO, Kim DH, Lee SW, Lee HS, Seo JH, Kim JH, Kim JH, Yu YS, Min BH, Kim KW
- KMID: 991623
- Exp Mol Med.
- 2011 Jan;43(1):53-61.
- doi: 10.3858/emm.2011.43.1.006
Clusterin is a secretory glycoprotein, which is highly up-regulated in a variety of normal and injury tissues undergoing apoptosis including infarct region of the myocardium. Here, we report that clusterin... -
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- betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin
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Lee BH, Bae JS, Park RW, Kim JE, Park JY, Kim IS
- KMID: 1111408
- Exp Mol Med.
- 2006 Apr;38(2):153-161.
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes involve the interaction of VSMCs with extracellular matrix proteins. Here,... -
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