- MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes
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Zhang Y, Jia J, Yang S, Liu X, Ye S, Tian H
- KMID: 2155344
- Exp Mol Med.
- 2014 Feb;46(2):e79.
- doi: 10.1038/emm.2013.152
Osteoarthritis is a common cause of functional deterioration in older adults and is an immense burden on the aging population. Altered chondrogenesis is the most important pathophysiological process involved in... -
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- miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
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Makki MS, Haqqi TM
- KMID: 2160620
- Exp Mol Med.
- 2015 Oct;47(10):e189.
- doi: 10.1038/emm.2015.66
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of... -
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