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Hypoxia Regulates the Extracellular Matrix via Mitogen-Activated Protein Kinases Pathway in Cells Retrieved from the Human Intervertebral Disc

Kang YM, Shin EJ, Lee BH, Yang JH, Lee HM, Moon SH

Purpose: The present study aimed to identify the physiological characteristics of cells by investigating the change in gene expression and protein levels during extracellular matrix (ECM) synthesis in the intervertebral...
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Downregulation of MicroRNA-495 Alleviates IL-1β Responses among Chondrocytes by Preventing SOX9 Reduction

Joung S, Yoon DS, Cho S, Ko EA, Lee KM, Park KH, Lee JW, Kim SH

Purpose: Our previous work demonstrated that miRNA-495 targets SOX9 to inhibit chondrogenesis of mesenchymal stem cells. In this study, we aimed to investigate whether miRNA-495-mediated SOX9 regulation could be a novel...
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Three-Dimensional Bioprinting Scaffolding for Nasal Cartilage Defects: A Systematic Review

Chiesa-Estomba CM, Aiastui A, González-Fernández I, Hernáez-Moya R, Rodinõ C, Delgado A, Garces JP, Paredes-Puente J, Aldazabal PP, Altuna X, Izeta A

BACKGROUND: In recent years, three-dimensional (3D)-printing of tissue-engineered cartilaginous scaffolds is intended to close the surgical gap and provide bio-printed tissue designed to fit the specific geometric and functional requirements...
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Cartilage tissue engineering for craniofacial reconstruction

Kim MS, Kim HK, Kim DW

Severe cartilage defects and congenital anomalies affect millions of people and involve considerable medical expenses. Tissue engineering offers many advantages over conventional treatments, as therapy can be tailored to specific...
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Current Concepts in the Articular Cartilage Repair

Yeo ED, Cho WJ, Lee YK

Articular cartilage defects are common in orthopedic practice. Most clinical and research efforts focus on restoring the damaged cartilage in connection with osteoarthritis or trauma. This article explains the current...
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Validation of the optimal scaffold pore size of nasal implants using the 3-dimensional culture technique

Nam JH, Lee SY, Khan G, Park ES

Background To produce patient-specific nasal implants, it is necessary to harvest and grow autologous cartilage. It is crucial to the proliferation and growth of these cells for scaffolds similar to...
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Evaluation of Collagen Gel-Associated Human Nasal Septum- Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair

Lim MH, Jeun JH, Kim DH, Park SH, Kim SJ, Lee WS, Hwang SH, Lim JY, Kim SW

BACKGROUND: Articular cartilage injury has a poor repair ability and limited regeneration capacity with therapy based on articular chondrocytes (ACs) implantation. Here, we validated the hypothesis that human nasal septum-derived...
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Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes

Seo YS, Cho IA, Kim TH, You JS, Oh JS, Lee GJ, Kim DK, Kim JS

The aim of the present study was to investigate the pathophysiological etiology of osteoarthritis that is mediated by the apoptosis of chondrocytes exposed to 25-hydroxycholesterol (25-HC), an oxysterol synthesized by...
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Rapid Cartilage Regeneration of Spheroids Composed of Human Nasal Septum-Derived Chondrocyte in Rat Osteochondral Defect Model

Jeon JH, Yun BG, Lim MJ, Kim SJ, Lim MH, Lim JY, Park SH, Kim SW

Background: Cell-based therapies have been studied for articular cartilage regeneration. Articular cartilage defects have little treatments because articular cartilage was limited regenerative capacity. Damaged articular cartilage is difficult to obtain...
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Current Updates in Treatment of Osteochondral Lesions of the Talus

Park YH, Kim JY, Kim HJ

Despite the increasing number of osteochondral lesions of the talus, there are a lack of definite evidence-based treatment protocols. Several types of treatments are available, each having their advantages and...
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Evaluation of Polycaprolactone-Associated Human Nasal Chondrocytes as a Therapeutic Agent for Cartilage Repair

Kim DH, Lim MH, Jeun JH, Park SH, Lee W, Park SH, Kwon MY, Hwang SH, Kim SW

BACKGROUND: In this study, we manufactured a complex of human nasal septal cartilage (hNC) with polycaprolactone (PCL) for transplantation into cartilaginous skeletal defects and evaluated their characteristics. METHODS: Nasal septum tissue...
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Effect of prednisolone on rabbit articular chondrocytes treated with sodium nitroprusside

Kang JS

This study was carried out to investigate the protective effect of prednisolone in rabbit primary cultured articular chondrocytes treated with sodium nitroprusside (SNP), a nitric oxide donor. After a cell...
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The Application of Fibrin/Hyaluronic Acid–Poly(L-Lactic-co-Glycolic Acid) Construct in Augmentation Rhinoplasty

Won HR, Kim YS, Won JE, Shin YS, Kim CH

Althoughmany graftmaterials have been used for augmentation rhinoplasty, an ideal graft has not yet been developed.As the field of tissue engineering has been developing, it has been applied to the...
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Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

Ra HJ, Oh MY, Kim HJ, Lee SY, Eom DW, Lee SK, Kim SN, Chung KS, Jang HJ

PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as...
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TGF-β1 upregulates the expression of hyaluronan synthase 2 and hyaluronan synthesis in culture models of equine articular chondrocytes

Ongchai S, Somnoo O, Kongdang P, Peansukmanee S, Tangyuenyong S

We investigated the effect of transforming growth factor beta 1 (TGF-β1) on equine hyaluronan synthase 2 (HAS2) gene expression and hyaluronan (HA) synthesis in culture models of articular chondrocytes. Equine...
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Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins

Ha SH, Kim HK, Anh NT, Kim N, Ko KS, Rhee BD, Han J

Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and...
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Regulation of Cartilage Development and Diseases by Transcription Factors

Nishimura , Hata K, Takahata Y, Murakami T, Nakamura E, Yagi H

Genetic studies and molecular cloning approaches have been successfully used to identify several transcription factors that regulate the numerous stages of cartilage development. Sex-determining region Y (SRY)-box 9 (Sox9) is...
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Effects of Type I Collagen Concentration in Hydrogel on the Growth and Phenotypic Expression of Rat Chondrocytes

Jin GZ, Kim HW

It is controversial whether type I collagen itself can maintain and improve chondrogenic phenotype of chondrocytes in a three-dimensional (3D) environment. In this study, we examined the effect of type...
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Transcriptional Network Controlling Endochondral Ossification

Hata K, Takahata Y, Murakami T, Nishimura

Endochondral ossification is the fundamental process of skeletal development in vertebrates. Chondrocytes undergo sequential steps of differentiation, including mesenchymal condensation, proliferation, hypertrophy, and mineralization. These steps, which are required for...
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Phytoestrogen (Daidzein) Promotes Chondrogenic Phenotype of Human Chondrocytes in 2D and 3D Culture Systems

Mahmod SA, Snigh S, Djordjevic I, Yee YM, Yusof R, Ramasamy T, Rothan HA

Clinical investigations have shown a significant relationship between osteoarthritis (OA) and estrogens levels in menopausalwomen. Therefore, treatment with exogenous estrogens has been shownto decrease the risk ofOA.However, the effect estrogen...
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