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Short-Term Effectiveness of Oral Nirmatrelvir/Ritonavir Against the SARS-CoV-2 Omicron Variant and Culture-Positive Viral Shedding

Lee E, Park S, Choi JP, Kim MK, Yang E, Ham SY, Lee S, Lee B, Yang JS, Park BK, Kim DS, Lee SY, Lee JY, Jang HC, Jeon J, Park SW

Background: Information on the effectiveness of nirmatrelvir/ritonavir against the omicron is limited. The clinical response and viral kinetics to therapy in the real world need to be evaluated. Methods: Mild to...
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Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

Chung Y, Kim EJ, Kim HS, Park KH, Baek JH, Kim J, Lee JY, Lee CS, Lim S, Kim SW, Kim ES, Shi HJ, Hong SH, Jun JB, Hong KW, Choi JP, Kim J, Yang KS, Yoon YK

Background: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. Methods:...
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Evaluation of Intervention Policies for the COVID-19 Epidemic in the Seoul/Gyeonggi Region through a Model Simulation

Seok J, Lee Y, Choi JY, Choi Jp, Seo H, Lee S, Lee J

Purpose: To evaluate the efficacy of intervention policies on coronavirus disease-19 (COVID-19) dissemination. Materials and Methods: An age-structured compartmental model for the COVID-19 outbreak was proposed to predict the impact of...
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The Role of Upper Airway Microbiome in the Development of Adult Asthma

Losol P, Choi JP, Kim SH, Chang YS

Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper...
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Factors Associated with Worsening Oxygenation in Patients with Non-severe COVID-19 Pneumonia

Hahm CR, Lee YK, Oh DH, Ahn MY, Choi JP, Kang NR, Oh J, Choi H, Kim S

Background: This study aimed to determine the parameters for worsening oxygenation in non-severe coronavirus disease 2019 (COVID-19) pneumonia. Methods: This retrospective cohort study included cases of confirmed COVID-19 pneumonia in a...
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Chest CT Findings of COVID-19 Patients with Mild Clinical Symptoms at a Single Hospital in Korea

Baek WY, Lee YK, Kim S, Hahm C, Ahn MY, Oh DH, Choi JP

Purpose: To retrospectively evaluate the chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) in patients with mild clinical symptoms at a single hospital in South Korea. Materials and Methods:...
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Clinical Experience with Use of Remdesivir in the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2: a Case Series

Lee C, Ahn MY, Byeon K, Choi JP, Hahm C, Kim H, Kim S, Kim TH, Oh J, Oh DH

Background: A novel antiviral agent, remdesivir (RDV), is a promising candidate treatment for coronavirus disease 2019 (COVID-19) in the absence of any proven therapy. Materials and Methods: This retrospective case series...
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Four cases of coronavirus disease 2019 in the early stage of pandemic of South Korea: a single public hospital experience

Ahn MY, Oh DH, Kim S, Choi JP, Lee JH, Lee YK, Hong KH

In view of this pandemic, as of February 2020, South Korea has the second highest number of confirmed cases in the world. Herein, we report four confirmed coronavirus disease 2019...
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Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells

Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS

PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. Peroxiredoxin-6, an important intracellular anti-oxidant...
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Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19

Kim ES, Chin BS, Kang CK, Kim NJ, Kang YM, Choi JP, Oh DH, Kim JH, Koh B, Kim SE, Yun NR, Lee JH, Kim JY, Kim Y, Bang JH, Song KH, Kim HB, Chung Kh, Oh Md, on behalf of the Korea National Committee for Clinical Management of COVID-19

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus...
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Incidence of Catheter-associated Urinary Tract Infection in Hospitals with Less than 300 Beds

Park JJ, Seo YB, Kim SR, Park HJ, Eom JS, Yoo H, Chun HK, Choi JP, Lee J

BACKGROUND: Catheter-associated urinary tract infection is a major infection in healthcare facilities. We investigated the urinary catheter utilization ratio and incidence of catheter-associated urinary tract infections in small-sized hospitals with...
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Multidrug-Resistant, Gram-Negative Bacteria in Hospitalized Elderly Patients from Non-Hospital Long-Term Care Facilities

Kim M, Shin J, Jeong Y, Cho J, Choi JP

BACKGROUND/AIMS: We investigated the risk of multidrug-resistant, gram-negative bacteria (MDRGNB) in hospitalized elderly patients from non-hospital long-term care facilities (LTCFs) and the antibiotic prescription pattern. METHODS: All clinical cultures obtained within...
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Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea

Choi JY, Oh JO, Ahn JY, Choi H, Kim JH, Seong H, Jeong SJ, Ku NS, Yeom JS, Choi JP

We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS...
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Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles

Kim MH, Choi SJ, Choi HI, Choi JP, Park HK, Kim EK, Kim MJ, Moon BS, Min TK, Rho M, Cho YJ, Yang S, Kim YK, Kim YY, Pyun BY

PURPOSE: The microbial environment is an important factor that contributes to the pathogenesis of atopic dermatitis (AD). Recently, it was revealed that not only bacteria itself but also extracellular vesicles...
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Correlation between Pneumonia Severity and Pulmonary Complications in Middle East Respiratory Syndrome

Park WB, Jun KI, Kim G, Choi JP, Rhee JY, Cheon S, Lee CH, Park JS, Kim Y, Joh JS, Chin BS, Choe PG, Bang JH, Park SW, Kim NJ, Lim DG, Kim YS, Oh MD, Shin HS

This nationwide, prospective cohort study evaluated pulmonary function and radiological sequelae according to infection severity in 73 survivors from the 2015 Middle East respiratory syndrome (MERS) outbreak in Korea. Patients...
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The Palliative Care and Hospice for the People Living with HIV

Choi JP

According to the advance of antiretroviral regimen and the early treatment strategy, people living with human immunodeficiency virus (PLWH) are achieving the goal of virologic suppression and immune restoration. Most...
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A Metagenomic Analysis Provides a Culture-Independent Pathogen Detection for Atopic Dermatitis

Kim MH, Rho M, Choi JP, Choi HI, Park HK, Song WJ, Min TK, Cho SH, Cho YJ, Kim YK, Yang S, Pyun BY

PURPOSE: Atopic dermatitis (AD) is an inflammatory skin disease, significantly affecting the quality of life. Using AD as a model system, we tested a successive identification of AD-associated microbes, followed...
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Neurological Complications during Treatment of Middle East Respiratory Syndrome

Kim JE, Heo JH, Kim HO, Song SH, Park SS, Park TH, Ahn JY, Kim MK, Choi JP

BACKGROUND AND PURPOSE: Middle East respiratory syndrome (MERS) has a high mortality rate and pandemic potential. However, the neurological manifestations of MERS have rarely been reported since it first emerged...
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Ileal epithelioid leiomyosarcoma with omental and peritoneal seeding

Kim CH, Kim SY, Jung CK, Choi JP, Seo KS, Lee JH, Choi JH

Leiomyosarcoma (LMS) of the small intestine is a rare tumor, accounting for about 1% of all malignant mesenchymal lesions in the gastrointestinal tract. Since small bowel tumors are initially asymptomatic...
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Helicobacter pylori-derived extracellular vesicles increased in the gastric juices of gastric adenocarcinoma patients and induced inflammation mainly via specific targeting of gastric epithelial cells

Choi HI, Choi JP, Seo J, Kim BJ, Rho M, Han JK, Kim JG

Evidence indicates that Helicobacter pylori is the causative agent of chronic gastritis and perhaps gastric malignancy. Extracellular vesicles (EVs) play an important role in the evolutional process of malignancy due...
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