- Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein
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Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ
- KMID: 2154241
- Exp Mol Med.
- 2013 May;45(5):e22.
The accumulation of abnormal protein aggregates is a major characteristic of many neurodegenerative disorders, including Parkinson's disease (PD). The intracytoplasmic deposition of alpha-synuclein aggregates and Lewy bodies, often found in... -
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- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
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Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ
- KMID: 1104391
- Exp Mol Med.
- 2011 Apr;43(4):216-222.
- doi: 10.3858/emm.2011.43.4.026
Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have... -
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- beta1-integrin-dependent migration of microglia in response to neuron-released alpha-synuclein
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Kim C, Cho ED, Kim HK, You S, Lee HJ, Hwang D, Lee SJ
- KMID: 2155356
- Exp Mol Med.
- 2014 Apr;46(4):e91.
- doi: 10.1038/emm.2014.6
Chronic neuroinflammation is an integral pathological feature of major neurodegenerative diseases. The recruitment of microglia to affected brain regions and the activation of these cells are the major events leading... -
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