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The Role of the Peripheral Chemokine, CCL3, in Hyperalgesia following Peripheral Nerve Injury in the Rat

Leem JW, Lee HJ, Nam TS, Yoon DM

BACKGROUND: Upregulation of one type of the pro-inflammatory chemokine (CCL2) and its receptor (CCR2) following peripheral nerve injury contributes to the induction of neuropathic pain. Here, we examined whether another...
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Effect of Leptin on the Expression of Chemokine Genes in THP-1 Cells

Choi JH, Park HS, Lee TY, Kim SK, Kim HS

BACKGROUND: Leptin is a 16-KDa non-glycosylated peptide hormone synthesized almost exclusively by adipocytes. The well-known function of leptin is regulation of food intake and energy expenditure. Leptin also plays a...
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Various CC Chemokine in Nasal Polyps and the Effect on CC Chemokine by Antibiotic Treatment

Yeo SG, Cho JS, Cha CI, Yoon SW

  • KMID: 2297701
  • J Rhinol.
  • 2001 May;8(1, 2):11-15.
BACKGROUND AND OBJECTIVES: The cause of nasal polyp is unsure but inflammation is thought to be an important factor in the development of nasal poyps. CC chemokine is a powerful...
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Plasma Macrophage Migration Inhibitory Factor and CCL3 as Potential Biomarkers for Distinguishing Patients with Nasopharyngeal Carcinoma from High-Risk Individuals Who Have Positive Epstein-Barr Virus Capsid Antigen-Specific IgA

Xue N, Lin JH, Xing S, Liu D, Li SB, Lai YZ, Wang XP, Mao MJ, Zhong Q, Zeng MS, Liu WL

PURPOSE: The purpose of this study was to identify novel plasma biomarkers for distinguishing nasopharyngeal carcinoma (NPC) patients from healthy individuals who have positive Epstein-Barr virus (EBV) viral capsid antigen...
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Expression of CXC and CC Chemokines in Gastric Mucosa Infected with Helicobacter pylori

Choi IJ, Kim JS, Jung HC, Kim JM, Lee KL, Song IS, Kim CY

  • KMID: 2304604
  • Korean J Gastroenterol.
  • 2000 Aug;36(2):163-174.
BACKGROUND/AIMS: To elucidate chemokine gene program in gastric mucosa infected with H. pylori, we quantified mRNA expression of CXC [growth-related oncogene alpha(GROalpha) and epithelial cell- derived neutrophil activating protein-78 (ENA-78)]...
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Expression of CC Chemokines in Nasal Polyps

Yeo SG, Cho JS, Cha CI, Lee JG, Lee CH, Kim KJ, Park KY

  • KMID: 1977717
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Nov;42(11):1376-1384.
BACKGROUND AND OBJECTIVES: The number of eosinophil in nasal polyps has been reported to be strongly elevated when compared to non-affected nasal tissue, indicating an important role for eosinophils in...
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The Analysis of the Cytokine Expression in Musculoskeletal Tumors

Lee JH, Kwak ES, Shon OJ, Kim HS, Shin DS

The cytokines are the hormone-like proteins, which are produced in the mononuclear cells. They have many roles, such as immune mediators, cell differentiations, angiogenesis. The chemokines have chemotactic effects which...
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Expression of MIP-1alpha mRNA in Kupffer Cells and Serum MIP-1alpha Post Portal Vein Transfusion

Park JK

  • KMID: 2003645
  • J Korean Soc Transplant.
  • 2002 Dec;16(2):167-171.
PURPOSE: Portal vein transfusion (PVT) has been known to induce immunosuppression or tolerance and Kupffer cell was identified to play an important role in the phenomenon. The purposes of this...
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IL-4-deficient Mice Aggravate Hypersensitivity Pneumonitis

Hwang SJ, Chung DH

BACKGROUND: Hypersensitivity pneumonitis (HP) comprises a group of lung diseases resulting from repeated inhalation of various antigens such as Saccharopolyspora rectivirgula (SR). HP is categorized as a Th1 disease. Therefore,...
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The Changes of Pro- and Anti-inflammatory Cytokines in Both Serum and Gastrocnemius Muscle of Mice after 2-hour Postischemic Reperfusion Injury

Kim SY

This study aimed to investigate the inflammatory changes and their main indicators according to the time-period of postischemic reperfusion injury confirmed by analyzing changes of both pro-inflammatory and anti-inflammatory cytokines...
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The Cholesterol-Binding Antibiotic Nystatin Induces Expression of Macrophage Inflammatory Protein-1 in Macrophages

Baek S, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K

  • KMID: 2170684
  • Biomol Ther.
  • 2013 Jan;21(1):42-48.
Nystatin, a polyene antifungal antibiotic, is a cholesterol sequestering agent. The antifungal agent alters composition of the plasma membrane of eukaryotic cells, whereas its effects on cells are poorly investigated....
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Serum Levels of IL-8 and ICAM-1 as Biomarkers for Progressive Massive Fibrosis in Coal Workers' Pneumoconiosis

Lee JS, Shin JH, Choi BS

Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study...
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Chemokine Secretion From Alveolar Macrophages in Patientswith Diffuse Interstitial Lung Diseases(DILD).

Kim DS, Paik SH, Man Lim C, Lee SD, Koh Y, Kim WS, Kim WD

BACKGROUND: The type of the infiltrating cells in alveolitis may be determined by the chemokines in the lesion. MIP-1alpha, a C-C type chemokine, stimulates proliferation and cytokine secretion from macrophages...
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Role of Protein Kinase C-delta in Atherosclerosis

Park SJ, Jung JP, Kim HJ, Lee EA, Kwon TW, Kwon B, Cho HR

PURPOSE: Protein kinase C (PKC) has been implicated in a wide variety of cellular processes. Although PKC-delta is implicated in cell growth inhibition, as well as in cell differentiation, apoptosis,...
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Role of Pertussis Toxin-sensitive G Protein-coupled Receptor Signaling in the Proliferation of Bone Marrow Mesenchymal Stem Cells

Kim SW, Hwang JH, Jin SA, Yun GW, Yang YJ, Park NW, Lee HJ, Yun HJ, Jo DY, Kim S

BACKGROUND: Bone marrow (BM) mesenchymal stem cells (MSCs) can be expanded over 20~30 cell doublings in vitro even in the absence of any growth factors. However, the mechanisms that govern...
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Induction of osteoclastogenesis-inducing cytokines and invasion by alive Aggregatibacter actinomycetemcomitans in osteoblasts

Choi HK, Lee YS, Kim MY, Kim KD, Cha JH, Yoo YJ

Osteoblasts regulate osteoclastogenesis by production of various cytokines. Aggregatibacter(A) actinomycetemcomitans is one of periodontopathogens which invades gingival tissue. Therefore, clarifying the effect of alive A. actinomycetemcomitans on osteoblasts is important...
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Association of Intracellular T(H)1-T(H)2 Balance in CD4+ T-cells and MIP-1alpha in CD8+ T-cells with Disease Severity in Adults with Dengue

Kadhiravan T, Saxena A, Singh A, Broor S, Sharma SK, Mitra DK

BACKGROUND: We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a T(H)1-skewed immune response as opposed to dengue fever (DF). METHODS: We estimated intracellular (in T-cells) and serum...
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Gene Expression Profiles in Genetically Different Mice Infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU

Ismail HA, Quan JH, Wei Z, Choi IW, Cha GH, Shin DW, Lee YH, Song CJ

Toxoplasma gondii can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after T. gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2,...
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Elevated monocyte chemoattractant protein-1 in patients with Behcet's disease

Do JH, Jung JH, Park CS, Ko JS, Kim SS, Choi HC, Son JM, Min DJ, Park SH, Cho CS, Kim HY, Kim WU

  • KMID: 2080961
  • Korean J Med.
  • 2003 Oct;65(4):458-466.
BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) belongs to C-C subfamily of chemokines, which stimulates the migration of monocytes. MCP-1 exerts various effects on the monocytes, including the induction of integrin and...
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The Regulation of Cytokine and Chemokine Expressions in Skin Xenograft by Aminoguanidine

Kim D, Kim JY, Ahn C, Yang MG, Lee EM, Yoon HY, Song M, Park CG, Ha J, Kim JG, Shin KS, Kim SJ, Lee JS

  • KMID: 2324294
  • J Korean Soc Transplant.
  • 2002 Jun;16(1):22-29.
PURPOSE: Previous reports demonstrated that nitric oxide (NO) plays immuno-regulatory role in immune responses including allograft rejection response. However, its possible role in xenograft rejection has not been examined. The...
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