- Deficiency of iNOS Does Not Prevent Isoproterenol-induced Cardiac Hypertrophy in Mice
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Cha HN, Hong GR, Kim YW, Kim JY, Dan JM, Park SY
- KMID: 2071665
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):153-159.
- doi: 10.4196/kjpp.2009.13.3.153
We investigated whether deficiency of inducible nitric oxide synthase (iNOS) could prevent isoproterenol-induced cardiac hypertrophy in iNOS knockout (KO) mice. Isoproterenol was continuously infused subcutaneously (15 mg/kg/day) using an osmotic... -
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- Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice
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Cha HN, Choi JH, Kim YW, Kim JY, Ahn MW, Park SY
- KMID: 2071709
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):377-384.
- doi: 10.4196/kjpp.2010.14.6.377
The present study examined whether metformin treatment prevents isoporterenol-induced cardiac hypertrophy in mice. Chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac... -
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