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Cholecystokinetic cholecysto-choledochography

Park HK, Bahk YW

Oral cholecystography is a reliable and the most popular clinical examination. The examination is not suitablefor morphological study of hte gallbladder but also efficient in diagnosing acalculous cholecystitis and cysticduct...
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Peroxisome Proliferator-activated Receptor-gamma Inhibits the Activation of STAT3 in Cerulein-stimulated Pancreatic Acinar Cells

Ju KD, Lim JW, Kim H

Cerulein-induced pancreatitis is similar to human edematous pancreatitis, characterized by the dysregulation of digestive enzyme production, edema formation, and an infiltration of inflammatory cells into the pancreas. We previously showed...
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The Role of Extracellular-signal-regulated Kinase and p38 in Trypsinogen Activation in Cerulein-Stimulated Rat Pancreatic Acini

Hwang JH, Kim YJ, Kim J, Jeong JB, Kim YT, Yoon YB, Kim CY

  • KMID: 1647122
  • Korean J Gastroenterol.
  • 2002 Oct;40(4):263-267.
BACKGROUND/AIMS: Intra-acinar cell activation of trypsinogen is a critical event in cerulein-induced pancreatitis. However, little is known about the intracellular signal transduction system that is involved in this process. The...
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The Severity of Acute Lung Injury in Experimental Acute Pancreatitis

Kim KH, Kim CD, Kim YS, Hyun JH

  • KMID: 2251398
  • Korean J Med.
  • 1998 Sep;55(3):295-301.
OBJECTIVES: About 60% of all deaths due to acute pancreatitis occur within the first 7 days of onset and associated with acute lung injuries. Lung injury include pulmonary infiltration, pulmonary...
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Effects of small molecular antioxidants on cerulein-induced acute pancreatitis in rat

Choi JY, Kim KH

  • KMID: 2071543
  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):629-635.
It has been suggested that oxygen free radicals are involved in the initiation process of acute pancreatitis, although its pathogenesis is not clear. This study evaluates the roles of oxygen radicals and...
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The Serum Tumor Necrosis Factor-alpha and Interleukin-1beta in Experimental Acute Pancreatitis of the Rat

Kim KH, Lee G, Lee HS, Kim CD, Hyun JH, Lim CS, Kim YS, Son MW, Kim WB, Ahn BO

  • KMID: 2038340
  • Korean J Gastroenterol.
  • 1999 Aug;34(2):238-244.
BACKGROUND/AIMS: To determine the role of cytokine in acute pancreatitis, we measured serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in experimental acute pancreatitis. METHODS: Acute pancreatitis (AP)...
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The Role of Nuclear Factor kB and Phosphatidylinositol 3 - kinase in Trypsinogen Activation in Cerulein - Stimulated Rat Pancreatic Acini

Kim YJ, Kim YT, Hwang JH, Kim J, Jeong JB, Yoon YB, Kim CY

  • KMID: 2085005
  • Korean J Gastroenterol.
  • 2001 Dec;38(6):427-432.
BACKGROUND/AIMS: Intra-acinar cell activation of trypsinogen is a critical event in cerulein-induced pancreatitis. However, little is known about the intracellular signal transduction systems involved in trypsinogen activation. This study focused...
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The Role of Heat Shock Protein 70 in the Pancreatic Trypsinogen Activation: Studies in Hsp70.1 Knock-out Mice

Hwang JH, Kim YT, Yoon YB, Jeong JB, Bae CJ, Seo JS, Kim CY

  • KMID: 1647238
  • Korean J Gastroenterol.
  • 2002 Nov;40(5):326-333.
BACKGROUND/AIMS: Heat shock proteins (Hsps) are expressed in the cell as a response to the external stimulation such as heat. There are some reports that the Hsp (i.e. Hsp70) is...
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Docosahexaenoic Acid Inhibits Expression of Fibrotic Mediators in Mice With Chronic Pancreatitis

Lee S, Jeong YK, Lim JW, Kim H

BACKGROUND: Chronic pancreatitis (CP) is an irreversible progressive disease that destroys exocrine parenchyma, which are replaced by fibrous tissue. As pancreatic fibrosis is a key feature of CP, reducing fibrotic...
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The Effect of 60-kDa Heat Shock Protein on Acute Experimental Pancreatitis

Lee G, Kim KH, Kim CD, Lee HS, Jeen YT, Chun HJ, Song CW, Um SH, Lee SW, Choi JH, Ryu HS, Hyun JH, Park IS

  • KMID: 1772571
  • Korean J Gastroenterol.
  • 1999 Dec;34(6):793-805.
BACKGROUND/AIMS: Recent studies showed that heat shock protein 60 (HSP60) might have a protective effect on experimental pancreatitis. However, protective mechanism of HSP60 is still unclear. The present study was...
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Free Oxygen Radicals in Cerulein Induced Acute Pancreatitis

Roe IH, Song IH, Kim JW, Yang MR, Kim JT, Lee JH, Park DG, Lim CY, Lee MI, Sohn SH, Jin YJ, Cho JH

  • KMID: 1547518
  • Korean J Gastroenterol.
  • 1997 Dec;30(6):808-814.
BACKGROUND/AIMS: Oxygen radicals are suggested to be an imponant role in the pathogenesis of acute pancreatitis in experimental animals. Cerulein is closely related to the cholecystokinin and it is a...
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Examination of protective and therapeutic effects of ruscogenin on cerulein-induced experimental acute pancreatitis in rats

Ercan G, Ä°lbar Tartar R, Solmaz A, Gulcicek O, Karagulle , Meric S, Cayoren H, Kusaslan R, Kemik A, Gokceoglu Kayali D, Cetinel S, Celik A

PURPOSE: To determine the potential protective and therapeutic effects and action mechanism of ruscogenin on cerulein-induced acute pancreatitis (AP) model in rats. METHODS: Overall, 32 rats were attenuated to the sham...
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The effect of nafamostat mesilate on the prevention of cerulein-induced acute pancreatitis

Lee JK, Park JK, Lee SH, Yoon WJ, Ryu JK, Kim YT, Jung HC, Yoon YB

  • KMID: 1962196
  • Korean J Med.
  • 2007 Apr;72(4):340-351.
BACKGROUND: Many protease inhibitors show a protective effect for acute pancreatitis as seen in animal models. In previous studies, the protease inhibitors were administered before induction of pancreatitis, and there...
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Sensitization to and Challenge with Gliadin Induce Pancreatitis and Extrapancreatic Inflammation in HLA-DQ8 Mice: An Animal Model of Type 1 Autoimmune Pancreatitis

Moon SH, Kim J, Kim MY, Park DH, Song TJ, Kim SA, Lee SS, Seo DW, Lee SK, Kim MH

BACKGROUND/AIMS: The aim of this study was to establish a pathogenetic mechanism of pancreatitis in celiac disease and IgG4-related disease using gluten-sensitive human leukocyte antigen (HLA)-DQ8 transgenic mice. METHODS: Transgenic mice...
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