- CKAP2 phosphorylation by CDK1/cyclinB1 is crucial for maintaining centrosome integrity
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Yoo BH, Kang DS, Park CH, Kang K, Bae CD
- KMID: 2388352
- Exp Mol Med.
- 2017 Jul;49(7):e354.
- doi: 10.1038/emm.2017.92
Previously, we have reported that CKAP2 is involved in the maintenance of centrosome integrity, thus allowing for proper mitosis in primary hepatocytes. To understand this biological process, we identified the... -
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- Alternative splicing in 5'-untranslational region of STK-15 gene, encoding centrosome associated kinase, in breast cancer cell lines
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Shin SO, Lee KH, Kim JH, Baek SH, Park JW, Gabrielson EW, Kwon TK
- KMID: 755098
- Exp Mol Med.
- 2000 Dec;32(4):193-196.
Centrosomes maintain genomic stability by establishing the bipolar spindles during cell division and, execute accurate segregation of chromosomes during mitosis. In this study, we have demonstrated that there... -
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- Centrosome amplification and multinuclear phenotypes are Induced by hydrogen peroxide
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Chae S, Yun C, Um H, Lee JH, Cho H
- KMID: 1089458
- Exp Mol Med.
- 2005 Oct;37(5):482-487.
Multinucleated cells resulted from mitosis defect have been noted in pathophysiological states of the cells such as inflammation, senescence and cancer. Since oxidative stress has been known to correlate with... -
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- IMMUNOHISTOCHEMICAL STUDY OF AURORA-2 KINASE IN THE ORAL SQUAMOUS CELL CARCINOMA
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Han SJ, Kim SW, Kim KW
- KMID: 2058671
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2010 Mar;32(2):112-117.
Aurora kinases represent a novel family of serine/threonine kinases crucial for cell cycle control. Aurora-2 kinase is mainly involved in centrosome function, mitotic entry, and spindle assembly. Aurora-2 kinase overexpression... -
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- Determination of Mother Centriole Maturation in CPAP-Depleted Cells Using the Ninein Antibody
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Lee M, Rhee K
- KMID: 2407104
- Endocrinol Metab.
- 2015 Mar;30(1):53-57.
- doi: 10.3803/EnM.2015.30.1.53
BACKGROUND: Mutations in centrosomal protein genes have been identified in a number of genetic diseases in brain development, including microcephaly. Centrosomal P4.1-associated protein (CPAP) is one of the causal genes... -
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- The centrosomal localization of KM-HN-1 (MGC33607) depends on the leucine zipper motif and the C-terminal coiled-coil domain
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Park HJ, Seo HJ, Kim HW, Kim JS, Hwang SY, Seong YS
- KMID: 1091078
- Exp Mol Med.
- 2007 Dec;39(6):828-838.
KM-HN-1 is a C-terminal coiled-coil domain containing protein previously referred to as image clone MGC33607. This protein has been previously identified as a cancer/testis antigen and reported as nuclear and... -
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- Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis
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Lee YK, Park I, Lee H
- KMID: 2384255
- Endocrinol Metab.
- 2014 Dec;29(4):561-566.
- doi: 10.3803/EnM.2014.29.4.561
BACKGROUND: Aneuploidy has been suggested as one of the major causes of cancer from the time of Boveri. In support of this notion, many studies have shown that cancer cells... -
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- Expression of polo-like kinase 1 in pre-implantation stage murine somatic cell nuclear transfer embryos
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Moon J, Roh S
- KMID: 2434771
- J Vet Sci.
- 2019 Jan;20(1):2-9.
- doi: 10.4142/jvs.2019.20.1.2
Somatic cell nuclear transfer (SCNT) has various applications in research, as well as in the medical field and animal husbandry. However, the efficiency of SCNT is low and the accurate... -
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- Relation between the Low Molecular Weight Cyclin E and Mutator Phenotype in Sporadic Colorectal Cancer
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Park DG
- KMID: 1940535
- J Korean Surg Soc.
- 2005 Sep;69(3):224-230.
PURPOSE: Cyclin E/CDK2 complexes are thought to play critical roles in multiple cell cycle events, including DNA replication, centrosome duplication, and activation of the E2F transcriptional program. Deregulation of the... -
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- Constitutional Pericentric Inversion 9 in Korean Patients with Chronic Myelogenous Leukemia
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Suh B, Song J, Kim J, Park TS, Choi JR
- KMID: 1781618
- Korean J Lab Med.
- 2010 Jun;30(3):218-223.
- doi: 10.3343/kjlm.2010.30.3.218
BACKGROUND: Although the pericentric inversion of chromosome 9, inv(9)(p11q13), is generally considered a normal variation, it is also associated with solid tumors and several hematologic malignancies such as biphenotypic acute... -
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