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p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest

Chae HD, Kim SY, Park SE, Kim J, Shin DY

We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin...
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ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response

Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS

Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase...
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IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1

Yu SJ, Kim HS, Cho SW, Sohn J

  • KMID: 1094082
  • Exp Mol Med.
  • 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the...
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