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The changing landscape in the management of newly diagnosed castration sensitive metastatic prostate cancer

Parker DC, Cookson MS

Metastatic prostate cancer is a heterogeneous disease entity. Men without prior androgen deprivation therapy exposure are termed metastatic castration sensitive prostate cancer (mCSPC). The goal of this article is to...
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Effectiveness of three different luteinizing hormone-releasing hormone agonists in the chemical castration of patients with prostate cancer: Goserelin versus triptorelin versus leuprolide

Shim M, Bang WJ, Oh CY, Lee YS, Cho JS

PURPOSE: To investigate the changes in testosterone levels and rates of chemical castration following androgen-deprivation therapy (ADT) with goserelin, triptorelin, and leuprolide. MATERIALS AND METHODS: We retrospectively reviewed the medical records...
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Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus

Shin MS, Kim TW, Park SS, Ko IG, Kim CJ, Kim M, Roh SY, Kim KT, Kim KH

PURPOSE: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine...
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Gonadotropin-releasing hormone immunization and castration in male pigs: effects on growth, hormonal levels, antibody titer response, testicular function, back fat, and consumers' sensory perceptions

Yamsakul P, Patchanee , Yano T, Boonma T, Somkert C, Sathanawongs A

This study investigated the effects of gonadotropin-releasing hormone (GnRH) vaccine on pig growth, carcass quality, and sensory perceptions of pork meat by Thai consumers. Male crossbred pigs (n = 30)...
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Expression of Heme Oxygenase-2 and Smooth Muscle Relaxation by Carbon Monoxide in Rat Prostate: Effects of Age and Castration

Oh HY, Kwon SM, Lee JR, Kim SI, Choi YD, Hong SJ

  • KMID: 2293476
  • Korean J Urol.
  • 2003 Jun;44(6):592-598.
PURPOSE: Carbon monoxide (CO), as well as nitric oxide (NO), have been proposed as potential effectors in the non-adrenergic, non-cholinergic (NANC), nerve-mediated relaxation of the prostate. Attempts were made to...
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Effects of Finasteride and Castration on Rat Ventral Prostate

Oh BR, Ahn KY, Kwon DD, Lim JH, Park KS, Ryu SB, Park YI

  • KMID: 1859349
  • Korean J Androl.
  • 2000 Apr;18(1):47-53.
PURPOSE: To compare the mechanism of cell loss and changes in the ventral prostate of young adult Sprague-Dawley rats after treatment with finasteride, a potent 5 alpha-reductase inhibitor, or castration. MATERIALS...
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Apoptosis in Ventral Lobe of Rat Prostate after Castration: Morhometric Measurement to Epithelial Cell Area

Lee GH, Sohng IH, Woo DS, Kim HJ

  • KMID: 2298651
  • Korean J Androl.
  • 2000 Dec;18(3):213-218.
PURPOSE: While apoptosis of the rat prostate cells has been the focus of many studies on androgen action and prostatic carcinogenesis, little is known for morphometric measurement about rat prostatic...
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The Morphological Heterogeneity after Castration in the Rat Prostatic Gland

Lee GH, Woo DS, Kim HJ

  • KMID: 2290324
  • Korean J Urol.
  • 1999 May;40(5):601-606.
PURPOSE: Prostate is a well known androgen dependent accessary sex organ and androgen plays major roles in growth and development of prostate. While rat prostate has been the focus of...
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Changes of the p57 and bcl-2 mRNA Expression in Human and Rat Prostates after Castration or 5alpha-reductase Inhibitor Administration

Lee GI, Bahk JY

  • KMID: 2060767
  • Korean J Urol.
  • 1999 Feb;40(2):193-200.
PURPOSE: The voiding difficulty in aged people is usually caused by prostate tumor and these tumors are influenced by the androgen. The purpose of this research was to study the...
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Effects of Castration on Apoptosis and p53 in the Adult Rat Penis

Choi YD, Park JA, Chung WS, Choi HK, Choi YJ

  • KMID: 2226758
  • Korean J Androl.
  • 1999 Dec;17(3):135-142.
PURPOSE: Androgen plays an important role during penile development and is essential for a normal libido in the male, but its role in the regulation of the androgen receptor (AR)...
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Effect of Finasteride or Castration on Rat Ventral Prostate

Lim JH, Oh BR, Ryu SB

  • KMID: 2290147
  • Korean J Urol.
  • 1998 Aug;39(8):717-722.
PURPOSE: We compared the extent of prostatic involution after treatment with finasteride, a potent 5alpha-reductase inhibitor, with those caused by castration. MATERIALS AND METHODS: Rats were divided into two...
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Morphological and Quantitative Analysis on the Expression of Bax in the Rat Prostate following Castration

Park MS, Kim SW, Choe G, Lee A, Lee E, Kim SW

  • KMID: 1881254
  • Korean J Urol.
  • 1998 Jul;39(7):622-626.
PURPOSE: Bax promotes apoptosis and is up-regulated by p53, which is not required for androgen ablation-induced apoptosis of the prostatic cells. We investigated the change of lax during the involution...
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The Properties of Glycoconjugates of Apoptotic Cell in the Rat Accessory Sex Gland after Castration

Moon YS, Kim KL, Baek SY, Kim JB, Kim JJ, Kim BS

  • KMID: 1530098
  • Korean J Anat.
  • 1998 Jun;31(3):371-386.
The present study was carried out to investigate the structure and the glycoconjugate properties of the apoptotic cells in the rat accessory sex glands (prostate gland, seminal vesicle and coagulating...
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Change of Sexual Function after Castration in Patients with Advanced Prostatic Carcinoma

Choi S, Yoo SJ, Rhew YY

  • KMID: 2290236
  • Korean J Urol.
  • 1998 Feb;39(2):157-161.
PURPOSE: The limited information regarding preservation of erectile function following castration is based on self-reports by castrated patients. Therefore, we evaluated the erectile status in 38 patients with advanced...
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The Effect of Testosterone on the Rat Penis and Accessory Sex Glands Following Castration

Choi S, Rhew HY, Yoon JB, Yeon SK

  • KMID: 1914378
  • Korean J Urol.
  • 1997 Aug;38(8):783-792.
Testosterone is required for the development and maintenance of the male accessory sex organs and their normal function. And it was reported that castration affect cells in the adult male...
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Comparative Study between the Effect of Finasteride & Castration on Rat Ventral Prostate

Kwon DD, Lim JH, Oh BR, Bang S, Park YI

No abstract available.
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Immunohistochemical Androgen Receptor Change of Relapsed Prostate Cancer After Castration

Choi HR, Han SW, Shim BS, Park YY, Kwon SW

  • KMID: 2060686
  • Korean J Urol.
  • 1996 Nov;37(11):1239-1246.
We tried to find out any differences between initial characteristics of androgen receptors and of relapse after castration in 6 stage D2 prostatic cancer (mean age, 68.7+/-4.6) (Gleason score 5,...
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The Effects of Castration and Sex Hormone Administration on Lactic and Malic Dehydrogenase Activities in the Testis and the Prostate Tissues of Male Rabbits

Kim HM, Choo KW

  • KMID: 1679463
  • Korean J Urol.
  • 1967 Jun;8(1):1-8.
As a process to study the mechanism of steroid hormones at the molecular level,the activities of lactic dehydrogenase (L.D.) and malic dehydrogenase (M.D.),NAD-linked transhydrogenases, were measured in the testis and...
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Effect of Castration and Sex Hormone Administration on Water and Electrolyte Distribution in Kidney, Smell Intestine and Lung of Male Rabbit

Kim BK, Choo KW

  • KMID: 2059937
  • Korean J Urol.
  • 1965 Dec;6(2):83-92.
One hundred and twenty male rabbits were divided into 8 groups in order to studythe effect of castration and sex hormone administration on water and electrolytesdistribution in kidney, small intestine...
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Experimental Studies on the Relation between Nicotine and Sexual Hormone: Part II. Effect of Castration and Sexual Hormone on Nicotine Toxicity

Lee YC

No abstract available.
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