- FLIP as an Anti-Cancer Therapeutic Target
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Yang JK
- KMID: 2396082
- Yonsei Med J.
- 2008 Feb;49(1):19-27.
Suppression of apoptosis is one of the hallmarks of carcinogenesis. Tumor cells endure apoptotic pressure by overexpressing several antiapoptotic proteins, and FLICE inhibitory protein (FLIP) is one of the important... -
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- Human Telomerase Reverse Transcriptase (hTERT): A Target Molecule for the Treatment of Cisplatin-resistant Tumors
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Park YP, Kim KD, Kang SH, Yoon DY, Park JW, Kim JW, Lee HG
- KMID: 1781577
- Korean J Lab Med.
- 2008 Dec;28(6):430-437.
- doi: 10.3343/kjlm.2008.28.6.430
BACKGROUND: Human telomerase reverse transcriptase (hTERT) is a catalytic enzyme that is required for telomerase activity (TA) and cancer progression. Telomerase inhibition or inactivation increases cellular sensitivity to UV irradiation,... -
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- Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging
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Kim MJ, Oh SJ, Park SH, Kang HJ, Won MH, Kang TC, Park JB, Kim JI, Kim J, Lee JY
- KMID: 1103677
- Exp Mol Med.
- 2007 Feb;39(1):14-26.
Primary neuronal culture is a powerful tool to study neuronal development, aging, and degeneration. However, cultured neurons show signs of cell death after 2 or 3 weeks. Although the mechanism... -
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