- Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction
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Chae YJ, Kim HS, Rhim HS, Kim BE, Jeong SW, Kim IK
- KMID: 1457543
- Exp Mol Med.
- 2001 Dec;33(4):284-292.
3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells. In this study, we analyzed the activation pathway of the caspase cascade involved... -
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- Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases
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Lee KB, Lee JS, Park JW, Huh TL, Lee YM
- KMID: 1103595
- Exp Mol Med.
- 2008 Feb;40(1):118-129.
- doi: 10.3858/emm.2008.40.1.118
Proton beam is useful to target tumor tissue sparing normal cells by allowing precise dose only into tumor cells. However, the cellular and molecular mechanisms by which proton beam induces... -
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- Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity
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Kim HS, Jeong SY, Lee JH, Kim BE, Kim JW, Jeong SW, Kim IK
- KMID: 755099
- Exp Mol Med.
- 2000 Dec;32(4):197-203.
3-Deazaadenosine (DZA), one of the potent inhibitors of S-adenosylhomocysteine hydrolase, is known to possess several biological properties including an induction of apoptosis. To evaluate a possibility that DZA... -
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- Cleavage of purified neuronal clathrin assembly protein (CALM) by caspase 3 and calpain
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Kim JA, Kim HL
- KMID: 1457537
- Exp Mol Med.
- 2001 Dec;33(4):245-250.
The most efficient means of protein internalization from the membrane are through clathrin-coated pits, which concentrate protein interactions with the clathrin-associated assembly protein complex AP-2 and internalization signals in the... -
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- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
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Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
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- Herba houttuyniae extract induces apoptotic death of human promyelocytic leukemia cells via caspase activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release
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Kwon KB, Kim EK, Shin BC, Seo EA, Yang JY, Ryu DG
- KMID: 1097256
- Exp Mol Med.
- 2003 Apr;35(2):91-97.
Herba houttuyniae has been used as a constituent of herval medicine prescriptions for the treatment of inflammation, cancer, and other diseases. In the present study, we investigated the cellular effects... -
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