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Recurrent Idiopathic Catatonia: Implications beyond the Diagnostic and Statistical Manual of Mental Disorders 5th Edition

Caroff SN, Hurford I, Bleier HR, Gorton GE, Campbell E

We describe a case of recurrent, life-threatening, catatonic stupor, without evidence of any associated medical, toxic or mental disorder. This case provides support for the inclusion of a separate category...
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Recent Advances in the Pharmacology of Tardive Dyskinesia

Caroff SN

Tardive dyskinesia (TD) is a syndrome of abnormal involuntary movements that follows treatment with dopamine D2-receptor antagonists. Recent approval of vesicular monoamine transporter-2 (VMAT2) inhibitors offers hope for reducing the...
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Drug-induced Hyperthermic Syndromes in Psychiatry

Caroff SN, Watson CB, Rosenberg H

Hyperthermia, or extreme elevations in body temperature, can be life-threatening and may be caused by prescription drugs or illegal substances acting at a number of different levels of the neuraxis....
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Risk of Neuroleptic Malignant Syndrome with Vesicular Monoamine Transporter Inhibitors

Caroff SN

Objective: Vesicular monoamine transporter-2 (VMAT2) inhibitors have been proven to be effective for the treatment of tardive dyskinesia and their use is likely to increase. The evidence base of published...
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Effect of Varenicline on Tardive Dyskinesia: A Pilot Study

Caroff SN, Gutman AR, Northrop J, Leong SH, Berkowitz RM, Campbell EC

Objective: Although evidence implicates striatal cholinergic impairment as a mechanism underlying tardive dyskinesia, trials of nonspecific cholinergic agents have been inconclusive. As a partial agonist at specific nicotinic receptor subtypes,...
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An Experimental Study to Assess the Professional and Social Consequences of Tardive Dyskinesia

Ayyagari R, Goldschmidt D, Mu F, Caroff SN, Carroll B

Objective: Antipsychotic medications may cause tardive dyskinesia (TD), an often-irreversible movement disorder characterized by involuntary movements that are typically stereotypic, choreiform, or dystonic and may impair quality of life. This...
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