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Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model

Owoyele BV, Bakare AO, Olaseinde OF, Ochu MJ, Yusuff AM, Ekebafe F, Fogabi OL, Roi T

Background: Inflammation is known to underlie the pathogenesis in neuropathic pain. This study investigated the anti-inflammatory and neuroprotective mechanisms involved in antinociceptive effects of co-administration of acetaminophen and L-carnosine in...
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Effects of carnosine and hypothermia combination therapy on hypoxic-ischemic brain injury in neonatal rats

Byun JC, Lee SR, Kim CS

Background: Carnosine has antioxidative and neuroprotective properties against hypoxic-ischemic (HI) brain injury. Hypothermia is used as a therapeutic tool for HI encephalopathy in newborn infants with perinatal asphyxia. However, the...
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L-histidine and L-carnosine exert anti-brain aging effects in D-galactose-induced aged neuronal cells

Kim Y, Kim Y

BACKGROUND/OBJECTIVES: Brain aging is a major risk factor for severe neurodegenerative diseases. Conversely, L-histidine and L-carnosine are known to exhibit neuroprotective effects. The aim of this study was to examine...
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The Neuroprotective Effects of Carnosine in Early Stage of Focal Ischemia Rodent Model

Park HS, Han KH, Shin JA, Park JH, Song KY, Kim DH

OBJECTIVE: This study was conducted to elucidate neuroprotective effect of carnosine in early stage of stroke. METHODS: Early stage of rodent stroke model and neuroblastoma chemical hypoxia model was established by...
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Biological functions of histidine-dipeptides and metabolic syndrome

Song BC, Joo NS, Aldini G, Yeum KJ

  • KMID: 2313704
  • Nutr Res Pract.
  • 2014 Feb;8(1):3-10.
The rapid increase in the prevalence of metabolic syndrome, which is associated with a state of elevated systemic oxidative stress and inflammation, is expected to cause future increases in the...
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Effects of alpha-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats

Kim MY, Kim EJ, Kim YN, Choi C, Lee BH

  • KMID: 2313547
  • Nutr Res Pract.
  • 2011 Oct;5(5):421-428.
alpha-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects...
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Effects of carnosine and related compounds on monosaccharide autoxidation and H2O2 formation

Lee BJ, Kang KS, Nam SY, Park JH, Lee YS, Yun YW, Cho MH

  • KMID: 2285219
  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):251-261.
The effects of carnosine and related compounds (CRCs) including anserine, homocarnosine, histidine, and beta-alanine on monosaccharide autoxidation and H2O2 formation were investigated. The incubation of CRCs with D-glucose, D-glucosamine, and D, L-glyceraldehyde at 37degreeC...
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