- Role of Calmodulin in the Generation of Reactive Oxygen Species and Apoptosis Induced by Tamoxifen in HepG2 Human Hepatoma Cells
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Lee YS
- KMID: 2071579
- Korean J Physiol Pharmacol.
- 2002 Aug;6(4):187-192.
Tamoxifen, an antiestrogen, has previously been shown to induce apoptosis in HepG2 human hepatoblastoma cells through activation of the pathways independent of estrogen receptors, i.e., intracellular Ca2+ increase and generation... -
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- A Memory Molecule, Ca2+/Calmodulin-Dependent Protein Kinase II and Redox Stress; Key Factors for Arrhythmias in a Diseased Heart
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Song YH
- KMID: 2224956
- Korean Circ J.
- 2013 Mar;43(3):145-151.
- doi: 10.4070/kcj.2013.43.3.145
Arrhythmias can develop in various cardiac diseases, such as ischemic heart disease, cardiomyopathy and congenital heart disease. It can also contribute to the aggravation of heart failure and sudden cardiac... -
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- Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization
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An M, Kim M
- KMID: 2133262
- Anat Cell Biol.
- 2015 Dec;48(4):235-243.
- doi: 10.5115/acb.2015.48.4.235
Kaempferol exerts cardioprotective actions through incompletely understood mechanisms. This study investigated the molecular mechanisms underlying the cardioprotective effects of kaempferol in sinus node dysfunction (SND) heart. Here, we demonstrate that... -
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- The Effects of Cyclosporin A on the Signal Transduction System in the Rat Brain
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Koo YJ, Kang UG, Roh MS, Ahn YM, Park JB, Kim YS
- KMID: 1985333
- Korean J Psychopharmacol.
- 2001 Dec;12(4):294-300.
The most important molecular mechanisms of intraneuronal signal transduction are those mediated by calcium and reversible protein phosphorylation. Although many studies pursued the activation of the protein kinases in the... -
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- Phasic and Tonic Inhibition are Maintained Respectively by CaMKII and PKA in the Rat Visual Cortex
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Joo K, Yoon SH, Rhie DJ, Jang HJ
- KMID: 2285555
- Korean J Physiol Pharmacol.
- 2014 Dec;18(6):517-524.
- doi: 10.4196/kjpp.2014.18.6.517
Phasic and tonic gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition critically regulate neuronal information processing. As these two inhibitory modalities have distinctive features in their receptor composition, subcellular localization of receptors, and... -
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- Modulation by the GABAB receptor siRNA of ethanol-mediated PKA-alpha, CaMKII, and p-CREB intracellular signaling in prenatal rat hippocampal neurons
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Lee HY, Yang BC, Lee ES, Chung JI, Koh PO, Park MS, Kim MO
- KMID: 1447433
- Anat Cell Biol.
- 2011 Sep;44(3):210-217.
- doi: 10.5115/acb.2011.44.3.210
Fetal alcohol syndrome (FAS) is a developmental neuropathology resulting from in utero exposure to ethanol; many of ethanol's effects are likely to be mediated by the neurotransmitter gamma-aminobutyric acid (GABA).... -
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- CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1alpha in Hepatoma Cells
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Lee KH
- KMID: 2071702
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):331-336.
- doi: 10.4196/kjpp.2010.14.5.331
In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O2 consumption and supply. Hypoxia Inducible Factor (HIF)-1alpha is a transcription factor responsible for tumor growth and angiogenesis... -
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- The Role of ATP on Reactive Oxygen Species Generation and Cellular Proliferation in BV-2 Cells
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Kim YH, Cho JK, Huh PW, Lim Y, Rha HK, Whang KT
- KMID: 2007391
- J Korean Child Neurol Soc.
- 2003 Nov;11(2):238-248.
PURPOSE: Adenosine triphosphate (ATP) evokes several cellular responses in microglia including propagation. However, the role of the purinoceptor on ROS generation in microglia is unclear. In order to determine the... -
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- The Memory-Enhancing Effects of Liquiritigenin by Activation of NMDA Receptors and the CREB Signaling Pathway in Mice
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Ko YH, Kwon SH, Hwang JY, Kim KI, Seo JY, Nguyen TL, Lee SY, Kim HC, Jang CG
- KMID: 2429049
- Biomol Ther.
- 2018 Mar;26(2):109-114.
- doi: 10.4062/biomolther.2016.284
Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification.... -
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- Brief low [Mg2+]o-induced Ca2+ spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons
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Kim HJ, Yang JS, Yoon SH
- KMID: 2150479
- Korean J Physiol Pharmacol.
- 2016 Jan;20(1):101-109.
- doi: 10.4196/kjpp.2016.20.1.101
Reducing [Mg2+]o to 0.1 mM can evoke repetitive [Ca2+]i spikes and seizure activity, which induces neuronal cell death in a process called excitotoxicity. We examined the issue of whether cultured... -
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- Simultaneous deletion of floxed genes mediated by CaMKIIalpha-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goalpha
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Choi CI, Yoon SP, Choi JM, Kim SS, Lee YD, Birnbaumer L, Suh-Kim H
- KMID: 2155358
- Exp Mol Med.
- 2014 May;46(5):e93.
- doi: 10.1038/emm.2014.14
The Cre/LoxP system is a well-established approach to spatially and temporally control genetic inactivation. The calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIalpha) promoter limits expression to specific regions of the... -
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- Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB
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Shin H, Park SY, Lee KB, Shin E, Nam SW, Lee JY, Jang JJ
- KMID: 1384056
- Korean J Hepatol.
- 2009 Dec;15(4):486-495.
- doi: 10.3350/kjhep.2009.15.4.486
BACKGROUND/AIMS: This study aimed to better understand gene expression profiles of human hepatic stellate cell (HSC) activation and the relationship with the Wnt signaling pathway. METHODS: The global transcript levels... -
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